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Compound Summary

General Compound Information

ethyl acetate

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Description

Ethyl acetate is the acetate ester formed between acetic acid and ethanol. It has a role as a polar aprotic solvent, an EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor, a metabolite and a Saccharomyces cerevisiae metabolite. It is an acetate ester, an ethyl ester and a volatile organic compound.

Synonyms

ETHYL ACETATE; 141-78-6; Ethyl ethanoate; Acetic acid ethyl ester; Acetoxyethane;

Vinegar naphtha;Acetic ether;Ethyl acetic ester;Acetic acid, ethyl ester;Acetidin;Ethylacetate;Essigester;Acetic ester;EtOAc;Aethylacetat;Ethylacetat;1-acetoxyethane;RCRA waste number U112;AcOEt;Ethylacetaat;Octan etylu;FEMA No. 2414;Etile (acetato di);Ethyle (acetate d');Ethylazetat;ethyl-acetate;CHEBI:27750;Ethylester kyseliny octove;acetic acid ethyl;Ethyl ester of acetic acid;MFCD00009171;NSC 70930;Essigsaeureethylester;Ethyl acetate [NF];acetic-acid-ethylester;Ethyl Acetate, HPLC;NSC-70930;CH3-CO-O-CH3;DTXSID1022001;76845O8NMZ;Ethyl acetate (NF);NCGC00091766-01;E1504;Ethyl acetate, ACS reagent;DTXCID602001;Essigester [German];Ethylacetaat [Dutch];Aethylacetat [German];Caswell No. 429;Octan etylu [Polish];Ethyl acetate (natural);Acetate d'ethyle;Acetato de etilo;Acetate d'ethyle [French];Acetato de etilo [Spanish];Ethyl acetate, ACS reagent, >=99.5%;CAS-141-78-6;HSDB 83;Etile (acetato di) [Italian];CCRIS 6036;Ethyle (acetate d') [French];Ethylester kyseliny octove [Czech];EINECS 205-500-4;UN1173;CH3COOC2H5;RCRA waste no. U112;EPA Pesticide Chemical Code 044003;ethylaceate;ethylactate;ethylacteate;Etylacetate;acet-ethylester;ehtyl acetate;ethanol acetate;ethly acetate;ethyl acteate;ethyl_acetate;ehyl acetate;ethl acetate;ethy acetate;ethyl aceate;ethyl actate;etyl acetate;UNII-76845O8NMZ;Acetyl ester;acet-eth-ester;AI3-00404;1-ethyl acetate;2~ethyl acetate;acetic ethyl ester;Etile(acetato di);Nat.Ethyl Acetate;Et-OAc;Ethyle(acetate d');acetic acid ethylester;Ethyl Acetate Natural;CH3CO2Et;Ethyl acetate HPLC grade;Ethyl acetate, for HPLC;Ethyl acetate, 99.9%;Ethyl acetate, ACS grade;CH3CO2CH2CH3;Epitope ID:116868;EC 205-500-4;ETHYL ACETATE [II];ETHYL ACETATE [MI];Ethyl acetate, HPLC Grade;CH3CO2C2H5;ETHYL ACETATE [FCC];ETHYL ACETATE [FHFI];ETHYL ACETATE [HSDB];ETHYL ACETATE [INCI];ETHYL ACETATE 100ML;Ethyl acetate, >=99.5%;WLN: 2OV1;CHEMBL14152;ACETIC ACID,ETHYL ESTER;ETHYL ACETATE [MART.];Ethyl acetate, AR, >=99%;Ethyl acetate, LR, >=99%;ETHYL ACETATE [USP-RS];ETHYL ACETATE [WHO-DD];Ethyl Acetate Reagent Grade ACS;2-Oxo-2-ethoxyethylidyne radical;Ethyl acetate, analytical standard;Ethyl acetate, Environmental Grade;ZINC895412;Ethyl acetate, anhydrous, 99.8%;NSC70930;Ethyl acetate, 99.9% low benzene;Tox21_111166;Tox21_202512;BDBM50128823;c0036;ETHYL ACETATE [EP MONOGRAPH];STL282717;Ethyl acetate, >=99%, FCC, FG;Ethyl acetate, HPLC grade, 99.8%;AKOS000121947;Ethyl acetate, Spectrophotometric Grade;UN 1173;Ethyl acetate, for HPLC, >=99.5%;Ethyl acetate, for HPLC, >=99.7%;Ethyl acetate, for HPLC, >=99.8%;Ethyl acetate, PRA grade, >=99.5%;NCGC00260061-01;Ethyl acetate, biotech. grade, >=99.8%;Ethyl acetate, ReagentPlus(R), >=99.5%;Ethyl acetate, ReagentPlus(R), >=99.8%;Ethyl acetate, tested according to Ph.Eur.;A0030;Ethyl acetate 100 microg/mL in Acetonitrile;Ethyl acetate, natural, >=99%, FCC, FG;Ethyl acetate, SAJ first grade, >=99.0%;FT-0621744;FT-0693343;Q0040;EN300-31487;Ethyl acetate [UN1173] [Flammable liquid];Ethyl acetate, for HPLC, >=99.8% (GC);Ethyl acetate, JIS special grade, >=99.5%;J3.639.860D;C00849;D02319;Ethyl acetate, capillary GC grade, >=99.5%;A807811;Q407153;Ethyl acetate, Laboratory Reagent, >=99.0% (GC);Ethyl acetate, UV-IR min. 99.8%, isocratic grade;J-007556;J-521240;F0001-0489;Ethyl acetate, puriss. p.a., ACS reagent, >=99.5% (GC);Ethyl acetate, United States Pharmacopeia (USP) Reference Standard;Ethylacetate, pure, meets the analytical specifications of Ph. Eur.;Ethyl Acetate, Pharmaceutical Secondary Standard; Certified Reference Material;Ethyl acetate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99.5% (GC);Ethyl acetate, puriss. p.a., free of higher boiling impurities, >=99.9% (GC);Ethyl acetate, puriss., meets analytical specification of Ph. Eur., BP, NF, >=99.5% (GC);

FlavorDB ID

2507

PUBCHEM ID

Molecular Weight

88.11 Molecular Formula

C4H8O2

Openeye Can Smiles

CCOC(=O)C

IUPAC Inchikey

XEKOWRVHYACXOJ-UHFFFAOYSA-N

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Toxicity Summary
Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database
IDENTIFICATION AND USE: Ethyl Acetate is a colorless liquid with a smell similar to glue or nail polish that is used as an industrial solvent. Ethyl Acetate is used as a solvent for chemical reactions. Because of its odor it is often used in cosmetics and its smell is associated with nail polishes. Additionally, it is used in confectionery, perfumes, and fruits because it evaporates at a fast rate, leaving but the scent of the perfume on the skin. Ethyl acetate is an effective poison for use in insect collector as its vapors are a respiratory tract irritant whose vapors can kill the insect quickly without destroying it, leaving it intact for study. HUMAN EXPOSURE AND TOXICITY: Short-term exposure to high levels of ethyl acetate results first in irritation of the eyes, nose and throat, followed by headache, nausea, vomiting, sleepiness, and unconsciousness. High concentrations can cause CNS depression and congestion of the liver and kidneys. Chronic poisoning has been described as producing anemia, leucocytosis (transient increase in the white blood cell count), and cloudy swelling, and fatty degeneration. Runners were evaluated after complaining of wheezing coughing, rhinitis, or shortness of breath after practicing in a facility under construction. Investigation revealed levels of ethyl acetate and toluene low enough to meet federal guidelines but apparently sufficient to cause symptoms in the athletes. Its carcinogenic properties are not known. Workers who in earlier years had been exposed to ethyl acetate concentrations of 300 mL/cu m and who were exposed at the time of the investigation to 16 mL/cu m were found to have normal sperm quality. ANIMAL STUDIES: In animals it has a narcotic effect at concentrations of over 5000 ppm. Repeated exposures of rabbits to 4450 ppm for 1 hr daily for 40 days resulted in anemia with leukocytosis, and damage to liver and kidneys. Male rats exposed to a high dose (3600 mg/kg/day) of ethyl acetate by gavage showed significant toxic effects, which resulted in depressed body and organ weights, and depressed food consumption. Female rats exposed to the high dose showed slight but non-significant depression of above parameters compared with controls. Exposure of rats to 750 and 1500 ppm ethyl acetate via inhalation for 6 hr per day, 5 days per week for 13 weeks, diminished behavioral responses to unexpected auditory stimuli during the exposure session and appeared to have an acute sedative effect. There were no signs of acute intoxication 30 min after exposure sessions ended. Rats exposed to 750 and 1500 ppm had reduced body weight, body weight gain, feed consumption, and feed efficiency, which fully or partially recovered within 4 weeks. Reductions in body weight gain and feed efficiency were observed in male rats exposed to 350 ppm. The principal behavioral effect of subchronic exposure was reduced motor activity in the 1500 ppm females, an effect that was not present after the 4-week recovery period. All other functional observation battery and motor activity parameters were unaffected, and no pathology was observed in nervous system tissues. In conclusion, there was no evidence that subchronic exposure up to 1500 ppm ethyl acetate produced any enduring neurotoxic effects in rats. Ethyl acetate is strong inducer of aneuploidy in the yeast Saccaromyces cerevisiae, but was negative for mutagenicity in Salmonella typhimurium assays. The solvent yielded negative result in the micronucleus assay in Chinese hamsters in vivo. In vivo hydrolysis of ethyl acetate to acetic acid and ethanol occurred rapidly. ECOTOXICITY STUDIES: Exposure of the common indian catfish (Heteropneustes fossilus) to 170 ppm of ethyl acetate for 3, 6, 12, 48, and 96 hr induced marked changes in carbohydrate metabolism. Hepatic glycogen levels declined significantly at 3, 48, and 96 hr, but there was no marked alteration in muscle glycogen content at any of the exposure periods. Hyperglycemia occurred at all time intervals. Blood pyruvate levels were elevated at 3, 6, 48, and 96 hr. Hyperlacticemia resulted at 3 and 96 hr, but hypolacticemia occurred at 6 and 12 hr. Impairment of carbohydrate metabolism might be responsible for the toxic action of ethyl acetate.
Source: DrugBank or Hazardous Substances Data Bank (HSDB)

Food Additive Safety (OFAS)
ETHYL ACETATE is used for COLOR OR COLORING ADJUNCT, FLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT, SOLVENT OR VEHICLE. More food additive safty information please view GRAS report.

EFSA's chemical Hazards Database : OpenFoodTox
This compound is found in OpenFoodTox with the name: Ethyl acetate

Reference point : Defined point on an experimental dose–response relationship for the critical effect. This term is synonymous to Point of departure (USA). Reference points include the lowest or no observed adverse effect level (LOAEL/NOAEL) or benchmark dose lower confidence limit (BDML), used to derive a reference value or Margin of Exposure in human and animal health risk assessment. In the ecological area, these include lethal dose (LD50), effect concentration (EC5/ECx), no (adverse) effect concentration/dose (NOEC/NOAEC/NOAED), no (adverse) effect level (NEL/NOAEL), hazard concentration (HC5/HCx) derived from a Species Sensitivity Distributions (SSD) for the ecosystem (EFSA Scientific Committee,2018). Citation: DOI 10.5281/zenodo.4740174

Output ID	SPECIES	Route	Duration Days	END POINT	QUALIFIER	VALUE	UNIT	EFFECT	Toxicity
2209	Rat	oral: gavage	90	NOAEL	=	900	mg/kg bw/day	body weight	systemic

Reference Value

Reference Value : The estimated maximum dose (on a body mass basis) or the concentration of an agent to which an individual may be exposed over a specified period without appreciable risk. Reference values are established by applying an uncertainty factor to the reference point. Examples of reference values in human health include acceptable daily intake (ADI) for food and feed additives, and pesticides, tolerable upper intake levels (UL) for vitamins and minerals, and tolerable daily intake (TDI) for contaminants and food contact materials. For acute effects and operators, the acute reference dose (ARfD) and the acceptable operator exposure level (AOEL). In animal health and the ecological area, these include safe feed concentrations and the Predicted no effect concentration (PNEC) respectively (EFSA Scientific Committee, 2018). Citation: DOI 10.5281/zenodo.4740174

OUTPUT ID	ASSESSMENT	QUALIFIER	VALUE	UNIT	POPULATION
586	ADI	<=	25	mg/kg bw/day	Consumers
2209	MSI/FC	=	9	mg/day	Chicken for egg production - adults
2209	MSI/FC	=	9	mg/day	Chicken for meat production
2209	MSI/FC	=	9	mg/day	Salmons
2209	MSI/FC	=	14	mg/day	Cats as pet
2209	MSI/FC	=	54	mg/day	Turkeys for meat production
2209	MSI/FC	=	68	mg/day	Dogs as pet
2209	MSI/FC	=	90	mg/day	Pigs - less than 1 year old
2209	MSI/FC	=	450	mg/day	Cattle for meat production - less than 1 year old
2209	MSI/FC	=	450	mg/day	Pigs for meat production - adults
2209	MSI/FC	=	900	mg/day	Pigs for reproduction - adults
2209	MSI/FC	=	1800	mg/day	Cattle for meat production - adults
2209	MSI/FC	=	2925	mg/day	Cattle for milk production - adults

Genotoxicity

Author	YEAR	OUTPUT ID	Genotoxicity
EFSA CONTAM	2011	586	Negative
EFSA FEEDAP	2013	2209	Not determined

EFSA Outputs

Output ID	Title	DOI	Published
586	Scientific Opinion on the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part I of III	doi:10.2903/j.efsa.2011.2482	19Dec2011
2209	Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species	doi:10.2903/j.efsa.2013.3169	05Apr2013

Receptors

Receptor information of this compound is not available!

Consensus Spectra

Spectrum Type	Spectrum View	Description	Polarity
Experimental GCMS	view	GCMS	positive

Content

Compound Summary

ethyl acetate

Description

Ethyl acetate is the acetate ester formed between acetic acid and ethanol. It has a role as a polar aprotic solvent, an EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor, a metabolite and a Saccharomyces cerevisiae metabolite. It is an acetate ester, an ethyl ester and a volatile organic compound.

Synonyms

ETHYL ACETATE; 141-78-6; Ethyl ethanoate; Acetic acid ethyl ester; Acetoxyethane;

FlavorDB ID

2507

PUBCHEM ID

8857

Molecular Weight

88.11

Molecular Formula

C4H8O2

Openeye Can Smiles

CCOC(=O)C

IUPAC Inchikey

XEKOWRVHYACXOJ-UHFFFAOYSA-N

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Content

Compound Summary

ethyl acetate

Description

Ethyl acetate is the acetate ester formed between acetic acid and ethanol. It has a role as a polar aprotic solvent, an EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor, a metabolite and a Saccharomyces cerevisiae metabolite. It is an acetate ester, an ethyl ester and a volatile organic compound.

Synonyms

ETHYL ACETATE; 141-78-6; Ethyl ethanoate; Acetic acid ethyl ester; Acetoxyethane;

FlavorDB ID

2507

PUBCHEM ID

8857

Molecular Weight

88.11

Molecular Formula

C4H8O2

Openeye Can Smiles

CCOC(=O)C

IUPAC Inchikey

XEKOWRVHYACXOJ-UHFFFAOYSA-N

Network

Shown in network

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OpenFoodTox: component Ethyl acetate

GC-MS Spectrum