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Compound Summary

General Compound Information

dimethyl sulfide

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Description

Dimethyl sulfide is a methyl sulfide in which the sulfur atom is substituted by two methyl groups. It is produced naturally by some marine algae. It has a role as a bacterial xenobiotic metabolite, a marine metabolite, an EC 3.5.1.4 (amidase) inhibitor, an algal metabolite and an Escherichia coli metabolite.

Synonyms

dimethyl sulfide; Methyl sulfide; 75-18-3; Methane, thiobis-; dimethyl sulphide;

dimethylsulfide;Methyl thioether;Dimethylsulphide;2-Thiapropane;Dimethyl thioether;Methyl sulphide;Methylthiomethane;Dimethylsulfid;(Methylsulfanyl)methane;METHYLSULFANYLMETHANE;Methyl monosulfide;Dimethyl monosulfide;Thiobismethane;2-Thiopropane;Methanethiomethane;Thiobis(methane);Exact-S;Sulfure de methyle;Dimethyl sulfide (natural);dimethylsulfane;FEMA No. 2746;Methylthiomethyl radical;Methane, 1,1'-thiobis-;[SMe2];QS3J7O7L3U;CHEBI:17437;(CH3)2S;methylsulfide;Dimethylsulfid [Czech];Sulfure de methyle [French];HSDB 356;EINECS 200-846-2;MFCD00008562;UN1164;UNII-QS3J7O7L3U;BRN 1696847;Methylsulphide;Thiopropane;Thiobis-methane;di-methylsulfide;AI3-25274;Dimethyl sulfane;Sulfide, methyl-;(methylthio)methane;Me2S;REDUCED-DMSO;SMe2;Nat. Dimethyl Sulfide;Dimethyl sulfide, 98%;reduced dimethyl sulfoxide;(Methylsulfanyl)methane #;Dimethyl sulfide [UN1164] [Flammable liquid];Dimethyl sulfide-[13C2];Dimethyl sulfoxide(Reduced);EC 200-846-2;(Me)2S;Dimethyl sulfide, >=99%;(Methylthiomethylidyne)radical;4-01-00-01275 (Beilstein Handbook Reference);CHEMBL15580;DIMETHYL SULFIDE [MI];METHYL SULFIDE [FHFI];DIMETHYL SULFIDE [FCC];DIMETHYL SULFIDE [HSDB];DTXSID9026398;S(CH3)2;Dimethyl sulfide, >=99%, FCC;Dimethyl sulfide, analytical standard;STL481894;Dimethyl sulfide, >=95.0% (GC);AKOS009031411;UN 1164;Dimethyl sulfide, anhydrous, >=99.0%;31533-72-9;M0431;Dimethyl sulfide, puriss., >=99.0% (GC);C00580;Dimethyl sulfide, natural, >=99%, FCC, FG;Dimethyl sulfide [UN1164] [Flammable liquid];A838342;Dimethyl sulfide, redistilled, >=99%, FCC, FG;Q423133;Q-100810;methyl sulphide, dimethyl sulphide, exact-S, thiobismethane;

FlavorDB ID

2557

PUBCHEM ID

Molecular Weight

62.14 Molecular Formula

C2H6S

Openeye Can Smiles

CSC

IUPAC Inchikey

QMMFVYPAHWMCMS-UHFFFAOYSA-N

Network

Similarity

CATEGORY	QUALITY	THRESHOLD	OCCURENCE	REFERENCE
smell		4.828e-3 µmol/L	meat	details
smell	asparagus-like	4.828e-3 µmol/L	jackfruit pulp	details
smell	asparagus-like, putrid	4.828e-3 µmol/L	cempedak	details
smell	rotten cabbage, decaying vegetation, canned corn		water	details
smell	rotten cabbage, decaying vegetation, canned corn	1.612e-2 µmol/L	water	details

Toxicity Summary
Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database

Food Additive Safety (OFAS)
METHYL SULFIDE is used for FLAVORING AGENT OR ADJUVANT. More food additive safty information please view GRAS report.

EFSA's chemical Hazards Database : OpenFoodTox
This compound is found in OpenFoodTox with the name: Dimethyl sulfide

Reference point : Defined point on an experimental dose–response relationship for the critical effect. This term is synonymous to Point of departure (USA). Reference points include the lowest or no observed adverse effect level (LOAEL/NOAEL) or benchmark dose lower confidence limit (BDML), used to derive a reference value or Margin of Exposure in human and animal health risk assessment. In the ecological area, these include lethal dose (LD50), effect concentration (EC5/ECx), no (adverse) effect concentration/dose (NOEC/NOAEC/NOAED), no (adverse) effect level (NEL/NOAEL), hazard concentration (HC5/HCx) derived from a Species Sensitivity Distributions (SSD) for the ecosystem (EFSA Scientific Committee,2018). Citation: DOI 10.5281/zenodo.4740174

Output ID	SPECIES	Route	Duration Days	END POINT	QUALIFIER	VALUE	UNIT	EFFECT	Toxicity
2318	Rat	oral: feed	98	NOAEL	=	250	mg/kg bw/day	no adverse effect observed at single/highest dose
2007	Rat	oral: gavage	98	NOAEL	=	250	mg/kg bw/day	no adverse effect observed at single/highest dose
2042	Rat	Not reported	98	NOEL	=	250	mg/kg bw/day	not reported	not reported
2056	Rat	oral: gavage	98	NOAEL	=	250	mg/kg bw/day	no adverse effect observed at single/highest dose
2082	Rat	oral: gavage	98	NOAEL	=	250	mg/kg bw/day	no adverse effect observed at single/highest dose
2120	Unspecified	Not reported	90	NOAEL	=	250	mg/kg bw/day	not reported	not reported
2121	Rat	oral: unspecified	90	NOAEL	=	250	mg/kg bw/day	not reported	not reported

Reference Value

Reference Value : The estimated maximum dose (on a body mass basis) or the concentration of an agent to which an individual may be exposed over a specified period without appreciable risk. Reference values are established by applying an uncertainty factor to the reference point. Examples of reference values in human health include acceptable daily intake (ADI) for food and feed additives, and pesticides, tolerable upper intake levels (UL) for vitamins and minerals, and tolerable daily intake (TDI) for contaminants and food contact materials. For acute effects and operators, the acute reference dose (ARfD) and the acceptable operator exposure level (AOEL). In animal health and the ecological area, these include safe feed concentrations and the Predicted no effect concentration (PNEC) respectively (EFSA Scientific Committee, 2018). Citation: DOI 10.5281/zenodo.4740174

Reference value information of this compound is not available!

Genotoxicity

Author	YEAR	OUTPUT ID	Genotoxicity
EFSA AFC	2009	2318	Not determined
EFSA CEF	2010	2007	Not determined
EFSA CEF	2010	2042	No data
EFSA CEF	2010	2056	Not determined
EFSA CEF	2011	2082	No data
EFSA CEF	2011	2120	No data
EFSA CEF	2011	2121	No data
EFSA FEEDAP	2013	2224	No data

EFSA Outputs

Output ID	Title	DOI	Published
2007	Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30	doi:10.2903/j.efsa.2010.1021	19Jul2010
2042	Scientific Opinion on Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)	doi:10.2903/j.efsa.2010.1337	05Oct2010
2056	Flavouring Group Evaluation 8, Revision 2 (FGE.08Rev2): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30	doi:10.2903/j.efsa.2010.1408	25Nov2010
2082	Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30	doi:10.2903/j.efsa.2011.1988	11May2011
2120	Scientific Opinion on Flavouring Group Evaluation 74, Revision 2 (FGE.74Rev2): Consideration of Simple Aliphatic Sulphides and Thiols evaluated by the JECFA (53rd and 61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08Rev3 (2011).	doi:10.2903/j.efsa.2011.2458	19Dec2011
2121	Scientific Opinion on Flavouring Group Evaluation 91, Revision 1 (FGE.91Rev1): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev3 (2011). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)	doi:10.2903/j.efsa.2011.2459	09Dec2011
2224	Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species	doi:10.2903/j.efsa.2013.3208	13May2013
2318	Flavouring Group Evaluation 8 (FGE.08): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20	doi:10.2903/j.efsa.2009.986	11Mar2009

Receptors

Receptor information of this compound is not available!

Consensus Spectra

Spectrum Type	Spectrum View	Description	Polarity
Experimental GCMS	view	GCMS	positive

Content

Compound Summary

dimethyl sulfide

Description

Synonyms

dimethyl sulfide; Methyl sulfide; 75-18-3; Methane, thiobis-; dimethyl sulphide;

FlavorDB ID

2557

PUBCHEM ID

1068

Molecular Weight

62.14

Molecular Formula

C2H6S

Openeye Can Smiles

CSC

IUPAC Inchikey

QMMFVYPAHWMCMS-UHFFFAOYSA-N

Network

Shown in network

Similarity

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Content

Compound Summary

dimethyl sulfide

Description

Synonyms

dimethyl sulfide; Methyl sulfide; 75-18-3; Methane, thiobis-; dimethyl sulphide;

FlavorDB ID

2557

PUBCHEM ID

1068

Molecular Weight

62.14

Molecular Formula

C2H6S

Openeye Can Smiles

CSC

IUPAC Inchikey

QMMFVYPAHWMCMS-UHFFFAOYSA-N

Network

Shown in network

Similarity

Show/Hide similarity panel

Reference Details

Reference Details

Reference Details

Reference Details

Reference Details

OpenFoodTox: component Dimethyl sulfide

GC-MS Spectrum