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Receptors

Compound Summary

General Compound Information

propanoic acid

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Description

Propionic acid is a short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group. It has a role as an antifungal drug. It is a short-chain fatty acid and a saturated fatty acid. It is a conjugate acid of a propionate.

Synonyms

propionic acid; Propanoic acid; 79-09-4; ethylformic acid; methylacetic acid;

Carboxyethane;Metacetonic acid;Ethanecarboxylic acid;Pseudoacetic acid;Luprosil;Monoprop;propionate;Prozoin;Antischim B;Propionoic acid;Acide propionique;Methyl acetic acid;Sentry grain preserver;C3 acid;Tenox P grain preservative;Caswell No. 707;Propionic acid grain preserver;FEMA No. 2924;Propionsaeure;Propcorn;Propkorn;propoic acid;Propioic acid;acide propanoique;Propionic acid (natural);Kyselina propionova;Acide propionique [French];Kyselina propionova [Czech];CCRIS 6096;proprionic acid;EPA Pesticide Chemical Code 077702;HSDB 1192;n-propionic acid;Toxi-Check;AI3-04167;CH3-CH2-COOH;UN1848;BRN 0506071;Propionic acid [NF];CHEBI:30768;JHU490RVYR;CHEMBL14021;INS NO.280;DTXSID8025961;INS-280;metacetonate;propanate;pseudoacetate;ethanecarboxylate;68937-68-8;68990-37-4;Propionic acid (NF);Propionic acid [UN1848] [Corrosive];E-280;Propionic acid, >=99.5%;Propanyl acid;FEMA Number 2924;EINECS 201-176-3;UNII-JHU490RVYR;MFCD00002756;Luprisol;proponic acid;1-propanoic acid;2-methylacetic acid;EINECS 273-079-4;EtCO2H;Propionic acid solution;Propionic acid, 99%;Propanoic acid (9CI);C2H5COOH;bmse000179;Epitope ID:139981;Propionic acid, >=99%;Propionic acid, 99.5%;EC 201-176-3;PROPIONIC ACID [MI];Propionic Acid Reagent Grade;NATURAL PROPIONIC ACID;Propionic acid (6CI,8CI);PROPIONIC ACID [FCC];4-02-00-00695 (Beilstein Handbook Reference);Propionic acid, 99%, FCC;PROPIONIC ACID [FHFI];PROPIONIC ACID [HSDB];PROPIONIC ACID [INCI];PROPIONIC ACID [VANDF];DTXCID505961;GTPL1062;PROPIONIC ACID [MART.];PROPIONIC ACID [USP-RS];PROPIONIC ACID [WHO-DD];AMY4114;Methylacetic Acid, Propanoic Acid;DTXSID001015846;Propionic acid, ACS reagent grade;Carboxymethoxylaminehemihydrochloride;Propionic acid, analytical standard;ZINC6050663;Propionic acid, natural, 99%, FG;Tox21_304030;BDBM50082199;LMFA01010003;STL168039;Propionic acid, feed grade, 98.7%;AKOS000118853;DB03766;UN 1848;CAS-79-09-4;Propionic acid, for synthesis, 99.5%;NCGC00357239-01;Propionic acid, >=99.5%, FCC, FG;BP-20411;E280;Propionic acid, ACS reagent, >=99.5%;FT-0637136;FT-0658557;P0500;EN300-19540;Propionic acid, SAJ first grade, >=98.0%;C00163;D02310;Propionic acid 1000 microg/mL in Acetonitrile;Propionic acid, puriss. p.a., >=99.5% (GC);Q422956;F2191-0098;Z104474154;Propionic acid, BioReagent, suitable for insect cell culture, ~99%;Propionic acid, United States Pharmacopeia (USP) Reference Standard;

FlavorDB ID

2587

PUBCHEM ID

Molecular Weight

74.08 Molecular Formula

C3H6O2

Openeye Can Smiles

CCC(=O)O

IUPAC Inchikey

XBDQKXXYIPTUBI-UHFFFAOYSA-N

Network

Similarity

Toxicity Summary
Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database
As a compound that is typically found naturally in the body, little to no adverse cumulative health effects have been associated with exposure to propionic acid [L2728]. Medical reports of acute exposures of workers to propionic acid show mild to moderate skin burns, mild eye redness, and one case of a mild cough and asthmatic response [L2728].
Source: DrugBank or Hazardous Substances Data Bank (HSDB)

Food Additive Safety (OFAS)
PROPIONIC ACID is used for ANTIMICROBIAL AGENT, FLAVORING AGENT OR ADJUVANT, PH CONTROL AGENT. More food additive safty information please view GRAS report.

EFSA's chemical Hazards Database : OpenFoodTox
This compound is found in OpenFoodTox with the name: Propionic acid

Reference point : Defined point on an experimental dose–response relationship for the critical effect. This term is synonymous to Point of departure (USA). Reference points include the lowest or no observed adverse effect level (LOAEL/NOAEL) or benchmark dose lower confidence limit (BDML), used to derive a reference value or Margin of Exposure in human and animal health risk assessment. In the ecological area, these include lethal dose (LD50), effect concentration (EC5/ECx), no (adverse) effect concentration/dose (NOEC/NOAEC/NOAED), no (adverse) effect level (NEL/NOAEL), hazard concentration (HC5/HCx) derived from a Species Sensitivity Distributions (SSD) for the ecosystem (EFSA Scientific Committee,2018). Citation: DOI 10.5281/zenodo.4740174

Reference point information of this compound is not available!

Reference Value

Reference Value : The estimated maximum dose (on a body mass basis) or the concentration of an agent to which an individual may be exposed over a specified period without appreciable risk. Reference values are established by applying an uncertainty factor to the reference point. Examples of reference values in human health include acceptable daily intake (ADI) for food and feed additives, and pesticides, tolerable upper intake levels (UL) for vitamins and minerals, and tolerable daily intake (TDI) for contaminants and food contact materials. For acute effects and operators, the acute reference dose (ARfD) and the acceptable operator exposure level (AOEL). In animal health and the ecological area, these include safe feed concentrations and the Predicted no effect concentration (PNEC) respectively (EFSA Scientific Committee, 2018). Citation: DOI 10.5281/zenodo.4740174

OUTPUT ID	ASSESSMENT	QUALIFIER	VALUE	UNIT	POPULATION
238	MSI/FC	=	10000	mg/kg	Poultry
238	MSI/FC	=	30000	mg/kg	Pigs

Genotoxicity

Author	YEAR	OUTPUT ID	Genotoxicity
EFSA ANS	2014	2523	Negative
EFSA FEEDAP	2006	289	No data
EFSA FEEDAP	2011	238	No data

EFSA Outputs

Output ID	Title	DOI	Published
238	Scientific Opinion on the safety and efficacy of propionic acid, sodium propionate, calcium propionate and ammonium propionate for all animal species	doi:10.2903/j.efsa.2011.2446	07Dec2011
289	Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of Kofa Grain -pH 5- (a mixture of sodium benzoate, propionic acid and sodium propionate) as a feed additive for cattle for fattening	doi:10.2903/j.efsa.2006.408	03Nov2006
2523	Scientific Opinion on the re-evaluation of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) as food additives	doi:10.2903/j.efsa.2014.3779	22Jul2014

Receptors

Receptor	REFERENCE	EC50 [µM]	Effective Concentration [µM]
OR51E2	details	Activated
OR52D1	details	Activated

Consensus Spectra

Spectrum Type	Spectrum View	Description	Polarity
Experimental GCMS	view	GCMS	positive
Experimental LCMS	view	LCMS_Positive	positive

Content

Compound Summary

propanoic acid

Description

Propionic acid is a short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group. It has a role as an antifungal drug. It is a short-chain fatty acid and a saturated fatty acid. It is a conjugate acid of a propionate.

Synonyms

propionic acid; Propanoic acid; 79-09-4; ethylformic acid; methylacetic acid;

FlavorDB ID

2587

PUBCHEM ID

1032

Molecular Weight

74.08

Molecular Formula

C3H6O2

Openeye Can Smiles

CCC(=O)O

IUPAC Inchikey

XBDQKXXYIPTUBI-UHFFFAOYSA-N

Network

Shown in network

Similarity

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Content

Compound Summary

propanoic acid

Description

Propionic acid is a short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group. It has a role as an antifungal drug. It is a short-chain fatty acid and a saturated fatty acid. It is a conjugate acid of a propionate.

Synonyms

propionic acid; Propanoic acid; 79-09-4; ethylformic acid; methylacetic acid;

FlavorDB ID

2587

PUBCHEM ID

1032

Molecular Weight

74.08

Molecular Formula

C3H6O2

Openeye Can Smiles

CCC(=O)O

IUPAC Inchikey

XBDQKXXYIPTUBI-UHFFFAOYSA-N

Network

Shown in network

Similarity

Show/Hide similarity panel

OpenFoodTox: component Propionic acid

Reference Details

Reference Details

GC-MS Spectrum

GC-MS Spectrum