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Compound Summary

General Compound Information

1-isopropenyl-4-methylbenzene

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Description

P-Mentha-1,3,5,8-tetraene is a monocyclic hydrocarbon and a monoterpene.

Synonyms

1195-32-0; 1-Methyl-4-(prop-1-en-2-yl)benzene; 4-Isopropenyltoluene; Dehydro-p-cymene; 2-P-Tolylpropene;

1-Methyl-4-(1-methylethenyl)benzene;alpha,p-Dimethylstyrene;1-Methyl-4-isopropenylbenzene;4-Methylisopropenylbenzene;2-(P-Methylphenyl)propene;p-cymenene;Isopropenyltoluene, p-;p,alpha-Dimethylstyrene;p-alpha-Dimethylstyrene;1-Isopropenyl-4-methylbenzene;1-methyl-4-prop-1-en-2-ylbenzene;p-alpha-Dimethyl styrene;Methyl-p-isopropenylbenzene;alpha-Methyl-P-methylstyrene;4-Methyl-alpha-methylstyrene;BENZENE, 1-METHYL-4-(1-METHYLETHENYL)-;FEMA No. 3144;p-Mentha-1,3,5,8-tetraene;NSC 361058;Styrene, p,.alpha.-dimethyl-;p-Isopropenyl toluene;p,.alpha.-Dimethylstyrene;1-methyl-4-prop-1-en-2-yl-benzene;XC8HY3OB86;ghl.PD_Mitscher_leg0.317;Methyl-4-(1-methylethenyl)-benzene;NSC-361058;1-Methyl-4-(1-methylethenyl)-benzene;Styrene, P-alpha-dimethyl-;27599-43-5;EINECS 214-795-9;Dimethylstyrene, p-alpha-;UNII-XC8HY3OB86;p-Methyl-alpha-methylstyrene;cymenene;p-isopropenyltoluene;NSC361058;Isopropenyl toluene c;P,alpha-Dimethylstyrol;alpha-p dimethylstyrene;4,alpha-Dimethylstyrene;alpha,4-Dimethylstyrene;alpha-Dimethyl-p-styrene;p,alpha-Dimethyl-Styrene;p-alpha-Dimethyl-Styrene;.alpha.,p-Dimethylstyrene;p,a-Dimethylstyrene, 8CI;.alpha.,4-Dimethylstyrene;para-alpha-dimethyl styrene;Para- alpha-dimethylstyrene;2-(4-Methylphenyl)propene;1-p-Tolyl-1-methylethylene;1-Methyl-4alpha-methylstyrene;para- .alpha.-Dimethylstyrene;p-Methyl-.alpha.-methylstyrene;4-Methyl-.alpha.-methylstyrene;DTXSID7047564;1-methyl-4.alpha.-methylstyrene;CHEBI:89920;FEMA 3144;1-Isopropenyl-4-methylbenzene #;4-CH3C6H4C(CH3)CH2;P-.ALPHA.-DIMETHYL STYRENE;BAA19532;ZINC1584796;DIMETHYLSTYRENE, P-.ALPHA.-;MFCD00036510;AKOS012525086;STYRENE, P-.ALPHA.-DIMETHYL-;P-.ALPHA.-DIMETHYL STYRENE [FHFI];1-Methyl-4-(1-methylethenyl)benzene, 9CI;FT-0622103;I0693;p,alpha-Dimethylstyrene, >=98%, stabilized;F17145;A804307;Q27162104;alpha,4-Dimethylstyrene, stabilized with 4-t-butylcatechol;

FlavorDB ID

2795

PUBCHEM ID

Molecular Weight

132.2 Molecular Formula

C10H12

Openeye Can Smiles

CC1=CC=C(C=C1)C(=C)C

IUPAC Inchikey

MMSLOZQEMPDGPI-UHFFFAOYSA-N

Network

Similarity

Toxicity Summary
Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database

Food Additive Safety (OFAS)
P,ALPHA-DIMETHYLSTYRENE is used for FLAVORING AGENT OR ADJUVANT. More food additive safty information please view GRAS report.

EFSA's chemical Hazards Database : OpenFoodTox
This compound is found in OpenFoodTox with the name: 1-Isopropenyl-4-methylbenzene

Reference point : Defined point on an experimental dose–response relationship for the critical effect. This term is synonymous to Point of departure (USA). Reference points include the lowest or no observed adverse effect level (LOAEL/NOAEL) or benchmark dose lower confidence limit (BDML), used to derive a reference value or Margin of Exposure in human and animal health risk assessment. In the ecological area, these include lethal dose (LD50), effect concentration (EC5/ECx), no (adverse) effect concentration/dose (NOEC/NOAEC/NOAED), no (adverse) effect level (NEL/NOAEL), hazard concentration (HC5/HCx) derived from a Species Sensitivity Distributions (SSD) for the ecosystem (EFSA Scientific Committee,2018). Citation: DOI 10.5281/zenodo.4740174

Output ID	SPECIES	Route	Duration Days	END POINT	QUALIFIER	VALUE	UNIT	EFFECT	Toxicity
2305	Rat	Not reported	90	NOAEL	=	0.625	mg/kg bw/day	not reported	not reported
2103	Rat	Not reported	90	NOAEL	=	0.625	mg/kg bw/day	not reported	not reported
2635	Rat	Not reported	90	NOAEL	=	0.625	mg/kg bw/day	not reported	not reported

Reference Value

Reference Value : The estimated maximum dose (on a body mass basis) or the concentration of an agent to which an individual may be exposed over a specified period without appreciable risk. Reference values are established by applying an uncertainty factor to the reference point. Examples of reference values in human health include acceptable daily intake (ADI) for food and feed additives, and pesticides, tolerable upper intake levels (UL) for vitamins and minerals, and tolerable daily intake (TDI) for contaminants and food contact materials. For acute effects and operators, the acute reference dose (ARfD) and the acceptable operator exposure level (AOEL). In animal health and the ecological area, these include safe feed concentrations and the Predicted no effect concentration (PNEC) respectively (EFSA Scientific Committee, 2018). Citation: DOI 10.5281/zenodo.4740174

OUTPUT ID	ASSESSMENT	QUALIFIER	VALUE	UNIT	POPULATION
2784	MSI/FC	=	1	mg/kg	Pigs
2784	MSI/FC	=	1	mg/kg	Poultry
2784	MSI/FC	=	1.5	mg/kg	Animal not used for food production - unspecified
2784	MSI/FC	=	1.5	mg/kg	Cattle
2784	MSI/FC	=	1.5	mg/kg	Salmons

Genotoxicity

Author	YEAR	OUTPUT ID	Genotoxicity
EFSA AFC	2009	2305	Not determined
EFSA CEF	2011	2103	Negative
EFSA CEF	2015	2635	Negative
EFSA FEEDAP	2015	2784	Not determined

EFSA Outputs

Output ID	Title	DOI	Published
2103	Scientific Opinion on Flavouring Group Evaluation 78, Revision 1 (FGE.78Rev1): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25Rev2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)	doi:10.2903/j.efsa.2011.2178	29Jun2011
2305	Flavouring Group Evaluation 78 (FGE.78): Consideration of Aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25. Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food	doi:10.2903/j.efsa.2009.931	20Jan2009
2635	Scientific Opinion on Flavouring Group Evaluation 78, Revision 2 (FGE.78Rev2): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic hydrocarbons evaluated by EFSA in FGE.25Rev3.	doi:10.2903/j.efsa.2015.4067	13Apr2015
2784	Scientific Opinion on the safety and efficacy of aliphatic and aromatic hydrocarbons (chemical group 31) when used as flavourings for all animal species	doi:10.2903/j.efsa.2015.4053	31Mar2015

Receptors

Receptor information of this compound is not available!

GC-MS Consensus Spectra

GC-MS Consensus Spectra information of this compound is not available!

Content

Compound Summary

1-isopropenyl-4-methylbenzene

Description

P-Mentha-1,3,5,8-tetraene is a monocyclic hydrocarbon and a monoterpene.

Synonyms

1195-32-0; 1-Methyl-4-(prop-1-en-2-yl)benzene; 4-Isopropenyltoluene; Dehydro-p-cymene; 2-P-Tolylpropene;

FlavorDB ID

2795

PUBCHEM ID

62385

Molecular Weight

132.2

Molecular Formula

C10H12

Openeye Can Smiles

CC1=CC=C(C=C1)C(=C)C

IUPAC Inchikey

MMSLOZQEMPDGPI-UHFFFAOYSA-N

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Content

Compound Summary

1-isopropenyl-4-methylbenzene

Description

P-Mentha-1,3,5,8-tetraene is a monocyclic hydrocarbon and a monoterpene.

Synonyms

1195-32-0; 1-Methyl-4-(prop-1-en-2-yl)benzene; 4-Isopropenyltoluene; Dehydro-p-cymene; 2-P-Tolylpropene;

FlavorDB ID

2795

PUBCHEM ID

62385

Molecular Weight

132.2

Molecular Formula

C10H12

Openeye Can Smiles

CC1=CC=C(C=C1)C(=C)C

IUPAC Inchikey

MMSLOZQEMPDGPI-UHFFFAOYSA-N

Network

Shown in network

Similarity

Show/Hide similarity panel

OpenFoodTox: component 1-Isopropenyl-4-methylbenzene