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Compound Summary

General Compound Information

Flufenamic acid

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Description

Flufenamic acid is an aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a non-steroidal anti-inflammatory drug, a non-narcotic analgesic and an antipyretic. It is an aromatic amino acid and an organofluorine compound. It derives from a diphenylamine, an anthranilic acid and a (trifluoromethyl)benzene. It is a conjugate acid of a flufenamate.

Synonyms

flufenamic acid; 530-78-9; Arlef; Fluphenamic acid; Nichisedan;

Achless;2-((3-(Trifluoromethyl)phenyl)amino)benzoic acid;Flufacid;Fullsafe;Lanceat;Paraflu;Plostene;Tecramine;Parlef;Parlif;Surika;Flufenaminsaeure;N-(3-Trifluoromethylphenyl)anthranilic acid;Reumajust A;Acido flufenamico;Ristogen;Sastridex;Ansatin;Meralen;Fluore-200;2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid;CI 440;NSC-82699;ANT-1;3'-Trifluoromethyldiphenylamine-2-carboxylic acid;Acide flufenamique;CN-27,554;Acidum flufenamicum;Benzoic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-;TVX 916;INF 1837;2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid;C.I. 440;2-[3-(Trifluoromethyl)anilino]benzoic acid;INF-1837;NSC 219007;Benzoic acid, 2-((3-(trifluoromethyl)phenyl)amino)-;N-(alpha,alpha,alpha-Trifluoro-m-tolyl)anthranilic acid;2-((3-Trifluromethyl)phenyl)aminobenzoic acid;2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID;N-(m-Trifluoromethylphenyl)-2-aminobenzoic acid;NSC-219007;60GCX7Y6BH;CHEMBL23588;MLS000028563;DTXSID7023063;CHEBI:42638;N-[3-(Trifluoromethyl)phenyl]anthranilic acid;Saal-F;CI-440;NCGC00016490-06;CAS-530-78-9;CN-27554;SMR000059027;N-(3-Trifluoromethylphenyl)-anthranilic acid;WLN: QVR BMR CXFFF;FFA;DTXCID303063;Flufenamicacid;N-(.alpha.,.alpha.,.alpha.-Trifluoro-m-tolyl)anthranilic acid;Flufenaminsaeure [German];Acido flufenamico [Italian];FLF;CCRIS 5266;2-[(3-Trifluromethyl)phenyl]aminobenzoic acid;N-[(3-Trifluoromethyl)phenyl]anthranilic acid;Acide flufenamique [INN-French];Acido flufenamico [INN-Spanish];Acidum flufenamicum [INN-Latin];N-((m-Trifluoromethyl)phenyl)-2-aminobenzoic acid;N-[(m-Trifluoromethyl)phenyl]-2-aminobenzoic acid;N-[m-(Trifluoromethyl)phenyl]-2-aminobenzoic acid;SR-01000000241;EINECS 208-494-1;Anthranilic acid,.alpha.,.alpha.-trifluoro-m-tolyl)-;N-(.alpha.,.alpha.-Trifluoro-m-tolyl)anthranilic acid;UNII-60GCX7Y6BH;Flufenamic acid [USAN:INN:BAN:JAN];BRN 1996069;flufenamic-acid;Prestwick_220;MFCD00002422;Arlef (TN);Spectrum_001257;1bm7;2-(3-Trifluoromethylanilino)benzoic Acid;Opera_ID_578;Prestwick0_000203;Prestwick1_000203;Prestwick2_000203;Prestwick3_000203;Spectrum2_000789;Spectrum3_001273;Spectrum4_000102;Spectrum5_000686;EC 208-494-1;CBiol_001756;SCHEMBL17497;BSPBio_000185;BSPBio_001319;BSPBio_002866;CBDivE_012649;FLUFENAMIC ACID [MI];KBioGR_000039;KBioGR_000424;KBioGR_002267;KBioSS_000039;KBioSS_001737;KBioSS_002268;3-14-00-00905 (Beilstein Handbook Reference);MLS001148610;DivK1c_000581;FLUFENAMIC ACID [INN];FLUFENAMIC ACID [JAN];SPECTRUM1501015;SPBio_000898;SPBio_002106;FLUFENAMIC ACID [USAN];BPBio1_000205;GTPL2447;FLUFENAMIC ACID [MART.];BCBcMAP01_000039;BDBM17636;HMS501N03;KBio1_000581;KBio2_000039;KBio2_001737;KBio2_002267;KBio2_002607;KBio2_004305;KBio2_004835;KBio2_005175;KBio2_006873;KBio2_007403;KBio3_000077;KBio3_000078;KBio3_002366;KBio3_002747;ZINC86535;Anthranilic acid, N-(alpha,alpha,alpha-trifluoro-m-tolyl)-;FLUFENAMIC ACID [WHO-DD];cMAP_000004;NINDS_000581;Bio1_000042;Bio1_000531;Bio1_001020;Bio2_000039;Bio2_000519;Flufenamic acid (JAN/USAN/INN);GLXC-27023;HMS1361B21;HMS1568J07;HMS1791B21;HMS1921B21;HMS1989B21;HMS2089E07;HMS2092B09;HMS2095J07;HMS2232G24;HMS3371F01;HMS3402B21;HMS3652F06;HMS3712J07;HMS3885P15;Pharmakon1600-01501015;HY-B1221;NSC82699;Tox21_110452;Tox21_302111;CCG-40167;NSC219007;NSC757823;s4268;STK985630;AKOS000265536;Tox21_110452_1;CS-4811;DB02266;KS-1143;NSC-757823;IDI1_000581;IDI1_033789;NCGC00016490-01;NCGC00016490-02;NCGC00016490-03;NCGC00016490-04;NCGC00016490-05;NCGC00016490-07;NCGC00016490-08;NCGC00016490-09;NCGC00016490-10;NCGC00016490-12;NCGC00023200-03;NCGC00023200-04;NCGC00023200-05;NCGC00023200-06;NCGC00023200-07;NCGC00255175-01;CN-27544;SBI-0051633.P002;DB-052254;2-[3-(trifluoromethyl)anilino]-benzoic acid;AB00052198;FT-0603454;n-(a,a,a-trifluoro-m-tolyl)anthranilic acid;SW196528-3;T2354;UNM000001246003;2-[3-(Trifluoromethyl)anilino]benzoic acid #;EN300-16858;2-(3-(trifluoromethyl)phenylamino)benzoic acid;2-[(3-Trifluoromethylphenyl)amino]benzoic Acid;A13333;D01581;D97458;AB00052198-14;AB00052198_15;Q416341;SR-01000000241-2;SR-01000000241-3;W-105772;BRD-K44067360-001-06-3;BRD-K44067360-001-16-2;Z56797275;F0909-0007;Flufenamic acid, analytical standard, for drug analysis;Anthranilic acid, N-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-;

FlavorDB ID

29

PUBCHEM ID

3371

Molecular Weight

281.23

Molecular Formula

C14H10F3NO2

Openeye Can Smiles

C1=CC=C(C(=C1)C(=O)O)NC2=CC=CC(=C2)C(F)(F)F

IUPAC Inchikey

LPEPZBJOKDYZAD-UHFFFAOYSA-N

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Compound Classification

Classification (Parent Nodes)

ClassyFire Ontology

Compound Quality

Quality information of this compound is not available!

Compound Toxicity and Food Additive Safety (OFAS)

Toxicity Summary
Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database

Receptors

Receptor	REFERENCE	EC50 [µM]	Effective Concentration [µM]
TAS2R14	details	Activated

Consensus Spectra

Spectrum Type	Spectrum View	Description	Polarity
Experimental LCMS	view	LCMS_Positive	positive
Experimental LCMS	view	LCMS_Negative	negative