Welcome to FlavorDB

Content

Generals
Classification
Quality
Toxicity & Safety
Receptors

Compound Summary

General Compound Information

1,8-cineole (eucalyptol)

Click to view/hide 3D structure

Description

1,8-cineole is a cineole. It has a role as a flavouring agent.

Synonyms

Eucalyptol; cineole; 1,8-Cineole; 470-82-6; Cajeputol;

1,8-Cineol;1,8-Epoxy-p-menthane;Eucalyptole;Eucapur;Zineol;Terpan;p-Cineole;1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane;Eukalyptol;1,8-Oxido-p-menthane;CINEOL;Cucalyptol;Soledum;p-Menthane, 1,8-epoxy-;Eukalyptol [Czech];Eucalyptol (natural);FEMA No. 2465;8000-48-4;2-Oxabicyclo[2.2.2]octane, 1,3,3-trimethyl-;Cineole (VAN);NCI-C56575;2-Oxabicyclo(2.2.2)octane, 1,3,3-trimethyl-;Eucaly;1,3,3-Trimethyl-2-oxabicyclo(2.2.2)octane;2-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane;NSC 6171;NSC-6171;NSC6171;2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane;2-Oxa-1,3,3-trimethylbicyclo[2.2.2]octane;RV6J6604TK;CNL;DTXSID4020616;4,7,7-trimethyl-8-oxabicyclo[2.2.2]octane;CHEBI:27961;Eucalyptol [USAN];NCGC00091666-01;NCGC00091666-04;DTXCID60616;Eucalyptol 1000 microg/mL in Methanol;UNII-RV6J6604TK;CAS-470-82-6;SMR000471853;CCRIS 3727;HSDB 991;Eucalyptol [USAN:USP];EINECS 207-431-5;MFCD00167977;(1s,4s)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane;Terpane;Cyneol;BIDD:ER0481;AI3-00578;Eucalyptol,(S);Eucalyptol (USP);1.8-cineole;1_8_cineole;Eucalyptol, 99%;Eucalyptol, Ph Helv;p-Menthane,8-epoxy-;EUCALYPTOL [II];EUCALYPTOL [MI];WLN: T66 A B AOTJ B1 B1 F1;CINEOLE [INCI];EUCALYPTOL [FCC];1,8-Cineol-[d3];CINEOLE [MART.];Spectrum2_000221;Spectrum3_000683;Spectrum4_001747;Spectrum5_000704;EUCALYPTOL [FHFI];EUCALYPTOL [HPUS];EUCALYPTOL [HSDB];EUCALYPTOL [INCI];CINEOLE [WHO-DD];EUCALYPTOL [VANDF];bmse000523;EC 207-431-5;EUCALYPTOL [USP-RS];SCHEMBL19622;SCHEMBL41020;BSPBio_002405;KBioGR_002194;MLS001050089;MLS001066338;DivK1c_000333;SPECTRUM1500294;SPBio_000261;CINEOLE [EP MONOGRAPH];Eucalyptol, analytical standard;CHEMBL485259;GTPL2464;CHEMBL1231862;CHEMBL1397305;SCHEMBL13554591;SCHEMBL17836873;SCHEMBL23876132;HMS501A15;KBio1_000333;KBio3_001625;EUCALYPTOL [USP IMPURITY];NINDS_000333;EUCALYPTOL [USP MONOGRAPH];HMS2271P04;Pharmakon1600-01500294;ZINC967566;HY-N0066;Tox21_111161;Tox21_202090;Tox21_302902;BDBM50459887;CCG-36080;NSC760388;AKOS015903223;AKOS016034339;AKOS037514637;Tox21_111161_1;CCG-266254;CS-8146;DB03852;LMPR0102090019;NSC-760388;IDI1_000333;Eucalyptol, tested according to Ph.Eur.;NCGC00091666-02;NCGC00091666-03;NCGC00091666-05;NCGC00095774-01;NCGC00178671-01;NCGC00256479-01;NCGC00259639-01;AC-20234;Eucalyptol, natural, >=99%, FCC, FG;LS-13868;NCI60_005108;1,3-Trimethyl-2-oxabicyclo[2.2.2]octane;2-Oxa-1,3-trimethylbicyclo[2.2.2]octane;DB-070775;2-Oxabicyclo[2.2.2]octane,3,3-trimethyl-;FT-0607033;FT-0626369;1,3,3-trimethyl-2-oxabicyclo[2,2,2]octane;A15662;C09844;D04115;AB01563262_01;Q161572;SR-01000763816;SR-01000763816-2;W-106080;1,8-Cineole, primary pharmaceutical reference standard;Cineole, European Pharmacopoeia (EP) Reference Standard;Eucalyptol, certified reference material, TraceCERT(R);F0001-1260;Eucalyptol, United States Pharmacopeia (USP) Reference Standard;Eucalyptol (cineole), Pharmaceutical Secondary Standard; Certified Reference Material;

FlavorDB ID

2923

PUBCHEM ID

Molecular Weight

154.25 Molecular Formula

C10H18O

Openeye Can Smiles

CC1(C2CCC(O1)(CC2)C)C

IUPAC Inchikey

WEEGYLXZBRQIMU-UHFFFAOYSA-N

Network

Similarity

CATEGORY	QUALITY	THRESHOLD	OCCURENCE	REFERENCE
smell	camphor,spicy, cool		water	details
smell	camphor,spicy, cool	7.785e-2 µmol/L	water	details

Toxicity Summary
Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database
Oral, rat LD50: 2480 mg/kg
Source: DrugBank or Hazardous Substances Data Bank (HSDB)

Food Additive Safety (OFAS)
EUCALYPTOL is used for FLAVORING AGENT OR ADJUVANT. More food additive safty information please view GRAS report.

EFSA's chemical Hazards Database : OpenFoodTox
This compound is found in OpenFoodTox with the name: 1,8-Cineole

Reference point : Defined point on an experimental dose–response relationship for the critical effect. This term is synonymous to Point of departure (USA). Reference points include the lowest or no observed adverse effect level (LOAEL/NOAEL) or benchmark dose lower confidence limit (BDML), used to derive a reference value or Margin of Exposure in human and animal health risk assessment. In the ecological area, these include lethal dose (LD50), effect concentration (EC5/ECx), no (adverse) effect concentration/dose (NOEC/NOAEC/NOAED), no (adverse) effect level (NEL/NOAEL), hazard concentration (HC5/HCx) derived from a Species Sensitivity Distributions (SSD) for the ecosystem (EFSA Scientific Committee,2018). Citation: DOI 10.5281/zenodo.4740174

Output ID	SPECIES	Route	Duration Days	END POINT	QUALIFIER	VALUE	UNIT	EFFECT	Toxicity
2156	Mouse	oral: capsule	28	NOAEL	=	562.5	mg/kg bw/day	other	hepatotoxicity

Reference Value

Reference Value : The estimated maximum dose (on a body mass basis) or the concentration of an agent to which an individual may be exposed over a specified period without appreciable risk. Reference values are established by applying an uncertainty factor to the reference point. Examples of reference values in human health include acceptable daily intake (ADI) for food and feed additives, and pesticides, tolerable upper intake levels (UL) for vitamins and minerals, and tolerable daily intake (TDI) for contaminants and food contact materials. For acute effects and operators, the acute reference dose (ARfD) and the acceptable operator exposure level (AOEL). In animal health and the ecological area, these include safe feed concentrations and the Predicted no effect concentration (PNEC) respectively (EFSA Scientific Committee, 2018). Citation: DOI 10.5281/zenodo.4740174

OUTPUT ID	ASSESSMENT	QUALIFIER	VALUE	UNIT	POPULATION
2156	MSI/FC	=	2	mg/day	Cats as pet
2156	MSI/FC	=	6	mg/day	Chicken for egg production
2156	MSI/FC	=	6	mg/day	Chicken for meat production
2156	MSI/FC	=	6	mg/day	Salmons
2156	MSI/FC	=	34	mg/day	Turkeys for meat production
2156	MSI/FC	=	42	mg/day	Dogs as pet
2156	MSI/FC	=	56	mg/day	Pigs - less than 1 year old
2156	MSI/FC	=	281	mg/day	Cattle for meat production - less than 1 year old
2156	MSI/FC	=	281	mg/day	Pigs for meat production - adults
2156	MSI/FC	=	563	mg/day	Pigs for reproduction - adults
2156	MSI/FC	=	1125	mg/day	Cattle for meat production - adults
2156	MSI/FC	=	1828	mg/day	Cattle for milk production - adults

Genotoxicity

Author	YEAR	OUTPUT ID	Genotoxicity
EFSA AFC	2008	2245	Negative
EFSA CEF	2011	2097	Negative
EFSA FEEDAP	2012	2156	Not determined

EFSA Outputs

Output ID	Title	DOI	Published
2097	Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)	doi:10.2903/j.efsa.2011.2158	11May2011
2156	Scientific Opinion on the safety and efficacy of aliphatic and alicyclic ethers (chemical group 16) when used as flavourings for all animal species	doi:10.2903/j.efsa.2012.2967	30Nov2012
2245	Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000)	doi:10.2903/j.efsa.2008.639	07Mar2008

Receptors

Receptor information of this compound is not available!

Consensus Spectra

Spectrum Type	Spectrum View	Description	Polarity
Experimental GCMS	view	GCMS	positive

Content

Compound Summary

1,8-cineole (eucalyptol)

Description

1,8-cineole is a cineole. It has a role as a flavouring agent.

Synonyms

Eucalyptol; cineole; 1,8-Cineole; 470-82-6; Cajeputol;

FlavorDB ID

2923

PUBCHEM ID

2758

Molecular Weight

154.25

Molecular Formula

C10H18O

Openeye Can Smiles

CC1(C2CCC(O1)(CC2)C)C

IUPAC Inchikey

WEEGYLXZBRQIMU-UHFFFAOYSA-N

Network

Shown in network

Similarity

Show/Hide similarity panel

Content

Compound Summary

1,8-cineole (eucalyptol)

Description

1,8-cineole is a cineole. It has a role as a flavouring agent.

Synonyms

Eucalyptol; cineole; 1,8-Cineole; 470-82-6; Cajeputol;

FlavorDB ID

2923

PUBCHEM ID

2758

Molecular Weight

154.25

Molecular Formula

C10H18O

Openeye Can Smiles

CC1(C2CCC(O1)(CC2)C)C

IUPAC Inchikey

WEEGYLXZBRQIMU-UHFFFAOYSA-N

Network

Shown in network

Similarity

Show/Hide similarity panel

Reference Details

Reference Details

OpenFoodTox: component 1,8-Cineole

GC-MS Spectrum