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Compound Summary

General Compound Information

2-acetyl-2-thiazoline

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Description

2-Acetyl-4,5-dihydrothiazole is a member of thiazoles.

Synonyms

2-Acetyl-2-thiazoline; 29926-41-8; 1-(4,5-dihydrothiazol-2-yl)ethanone; 1-(4,5-Dihydro-1,3-thiazol-2-yl)ethanone; Ethanone, 1-(4,5-dihydro-2-thiazolyl)-;

2-acetylthiazoline;2-Acetyl-4,5-dihydrothiazole;2-Thiazoline, 2-acetyl;TI3K1Q5Y1T;Ketone, methyl 2-thiazolin-2-yl;1-(4,5-dihydro-1,3-thiazol-2-yl)ethan-1-one;UNII-TI3K1Q5Y1T;acetylthiazoline;Corn thiazoline;1-(4,5-dihydrothiazol-2-yl)ethan-1-one;SCHEMBL689553;2-Acetyl-2-thiazoline, 99%;FEMA NO. 3817;CHEBI:89714;FEMA 3817;DTXSID60184037;2-Acetyl-2-thiazoline, >=96%;AMY14187;BCP17112;ZINC5159440;MFCD00209496;AKOS015898789;2-ACETYL-2-THIAZOLINE [FHFI];AC-6727;CS-W002515;Methyl 2-thiazolin-2-yl ketone, 8CI;2-Acetyl-2-thiazoline, >=96%, FG;METHYL 2-THIAZOLIN-2-YL KETONE;1-(4,5-Dihydro-2-thiazolyl)-Ethanone;AS-35552;DB-003251;1-(4,5-Dihydro-2-thiazolyl)ethanone, 9CI;A5536;FT-0690664;J-200137;Q27161906;

FlavorDB ID

2955

PUBCHEM ID

Molecular Weight

129.18 Molecular Formula

C5H7NOS

Openeye Can Smiles

CC(=O)C1=NCCS1

IUPAC Inchikey

FZOZFDAMVVEZSJ-UHFFFAOYSA-N

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Similarity

CATEGORY	QUALITY	THRESHOLD	OCCURENCE	REFERENCE
smell	roasty	1.548e-7 µmol/L	maillard product	details
smell		3.871e-7 µmol/L	maillard product	details
smell	roasty, nutty	6.115e-4 µmol/L	chicken egg omlette	details
smell		6.115e-4 µmol/L	blanched prawn fried prawn	details
smell	roasty	2.400e+0 µg/kg	pretzel	details

Toxicity Summary
Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database

Food Additive Safety (OFAS)
2-ACETYL-2-THIAZOLINE is used for FLAVORING AGENT OR ADJUVANT. More food additive safty information please view GRAS report.

EFSA's chemical Hazards Database : OpenFoodTox
This compound is found in OpenFoodTox with the name: 2-Acetyl-2-thiazoline

Reference point : Defined point on an experimental dose–response relationship for the critical effect. This term is synonymous to Point of departure (USA). Reference points include the lowest or no observed adverse effect level (LOAEL/NOAEL) or benchmark dose lower confidence limit (BDML), used to derive a reference value or Margin of Exposure in human and animal health risk assessment. In the ecological area, these include lethal dose (LD50), effect concentration (EC5/ECx), no (adverse) effect concentration/dose (NOEC/NOAEC/NOAED), no (adverse) effect level (NEL/NOAEL), hazard concentration (HC5/HCx) derived from a Species Sensitivity Distributions (SSD) for the ecosystem (EFSA Scientific Committee,2018). Citation: DOI 10.5281/zenodo.4740174

Output ID	SPECIES	Route	Duration Days	END POINT	QUALIFIER	VALUE	UNIT	EFFECT	Toxicity
2378	Rat	oral: feed	90	NOAEL	=	1.8	mg/kg bw/day	no adverse effect observed at single/highest dose
2379	Rat	Not reported	90	NOAEL	=	1.8	mg/kg bw/day	not reported	not reported

Reference Value

Reference Value : The estimated maximum dose (on a body mass basis) or the concentration of an agent to which an individual may be exposed over a specified period without appreciable risk. Reference values are established by applying an uncertainty factor to the reference point. Examples of reference values in human health include acceptable daily intake (ADI) for food and feed additives, and pesticides, tolerable upper intake levels (UL) for vitamins and minerals, and tolerable daily intake (TDI) for contaminants and food contact materials. For acute effects and operators, the acute reference dose (ARfD) and the acceptable operator exposure level (AOEL). In animal health and the ecological area, these include safe feed concentrations and the Predicted no effect concentration (PNEC) respectively (EFSA Scientific Committee, 2018). Citation: DOI 10.5281/zenodo.4740174

Reference value information of this compound is not available!

Genotoxicity

Author	YEAR	OUTPUT ID	Genotoxicity
EFSA CEF	2009	2036	Ambiguous
EFSA CEF	2013	2378	Negative
EFSA CEF	2013	2379	Negative

EFSA Outputs

Output ID	Title	DOI	Published
2036	Flavouring Group Evaluation 93 (FGE.93): Consideration of sulphur containing heterocyclic compounds evaluated by JECFA (68th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives evaluated by EFSA in FGE.21Rev1 (2009). Scientific Opinion of the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)	doi:10.2903/j.efsa.2009.1206	15Sep2009
2378	Scientific Opinion on Flavouring Group Evaluation 21, Revision 4 (FGE.21Rev4): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)	doi:10.2903/j.efsa.2013.3451	15Nov2013
2379	Scientific Opinion on Flavouring Group Evaluation 93, Revision 1 (FGE.93Rev1): Consideration of sulphur containing heterocyclic compounds evaluated by JECFA (68th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives evaluated by EFSA in FGE.21Rev3. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)	doi:10.2903/j.efsa.2013.3452	15Nov2013

Receptors

Receptor information of this compound is not available!

GC-MS Consensus Spectra

GC-MS Consensus Spectra information of this compound is not available!

Content

Compound Summary

2-acetyl-2-thiazoline

Description

2-Acetyl-4,5-dihydrothiazole is a member of thiazoles.

Synonyms

2-Acetyl-2-thiazoline; 29926-41-8; 1-(4,5-dihydrothiazol-2-yl)ethanone; 1-(4,5-Dihydro-1,3-thiazol-2-yl)ethanone; Ethanone, 1-(4,5-dihydro-2-thiazolyl)-;

FlavorDB ID

2955

PUBCHEM ID

169110

Molecular Weight

129.18

Molecular Formula

C5H7NOS

Openeye Can Smiles

CC(=O)C1=NCCS1

IUPAC Inchikey

FZOZFDAMVVEZSJ-UHFFFAOYSA-N

Network

Shown in network

Similarity

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Content

Compound Summary

2-acetyl-2-thiazoline

Description

2-Acetyl-4,5-dihydrothiazole is a member of thiazoles.

Synonyms

2-Acetyl-2-thiazoline; 29926-41-8; 1-(4,5-dihydrothiazol-2-yl)ethanone; 1-(4,5-Dihydro-1,3-thiazol-2-yl)ethanone; Ethanone, 1-(4,5-dihydro-2-thiazolyl)-;

FlavorDB ID

2955

PUBCHEM ID

169110

Molecular Weight

129.18

Molecular Formula

C5H7NOS

Openeye Can Smiles

CC(=O)C1=NCCS1

IUPAC Inchikey

FZOZFDAMVVEZSJ-UHFFFAOYSA-N

Network

Shown in network

Similarity

Show/Hide similarity panel

Reference Details

Reference Details

Reference Details

Reference Details

Reference Details

OpenFoodTox: component 2-Acetyl-2-thiazoline