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Classification
Quality
Toxicity & Safety
Receptors

Compound Summary

General Compound Information

4-vinylphenol

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Description

4-hydroxystyrene is a member of the class of phenols that is styrene carrying a hydroxy substituent at position 4. It has a role as a human urinary metabolite and a human xenobiotic metabolite. It derives from a hydride of a styrene.

Synonyms

4-Vinylphenol; 4-Hydroxystyrene; 2628-17-3; 4-ETHENYLPHENOL; p-Vinylphenol;

p-Hydroxystyrene;Phenol, 4-ethenyl-;4-Vinylphenol, 10 wt.% In propylene glycol;Phenol, P-vinyl-;FEMA No. 3739;4-vinyl phenol;OA7V1SM8YL;CHEBI:1883;CHEMBL349881;EINECS 220-103-6;UNII-OA7V1SM8YL;BRN 0506844;paravinyl phenol;4-VP;p-vinyl phenol;Para-vinylphenol;4-Ethenyl-phenol;4-Vinyl-Phenol;4-Hydroxy styrene;VINYLPHENOL, P-;SCHEMBL59328;P-VINYLPHENOL [FHFI];4-06-00-03775 (Beilstein Handbook Reference);DTXSID7073301;SCHEMBL13341430;ZINC895826;AMY18684;BDBM50017833;MFCD00017593;NSC114470;AKOS015891246;CS-W005288;DS-6347;HY-W005288;NSC-114470;4-Vinylphenol 10 wt.% In propylene glycol;DB-008431;FT-0618751;C05627;EN300-252561;Q4637201;W-107182;

FlavorDB ID

3050

PUBCHEM ID

Molecular Weight

120.15 Molecular Formula

C8H8O

Openeye Can Smiles

C=CC1=CC=C(C=C1)O

IUPAC Inchikey

FUGYGGDSWSUORM-UHFFFAOYSA-N

Network

Similarity

CATEGORY	QUALITY	THRESHOLD	OCCURENCE	REFERENCE
smell		2.100e+3 µg/kg	gluten-free rice bread wheat bread	details

Toxicity Summary
Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database

Food Additive Safety (OFAS)
P-VINYLPHENOL is used for FLAVORING AGENT OR ADJUVANT. More food additive safty information please view GRAS report.

EFSA's chemical Hazards Database : OpenFoodTox
This compound is found in OpenFoodTox with the name: 4-Vinylphenol

Reference point : Defined point on an experimental dose–response relationship for the critical effect. This term is synonymous to Point of departure (USA). Reference points include the lowest or no observed adverse effect level (LOAEL/NOAEL) or benchmark dose lower confidence limit (BDML), used to derive a reference value or Margin of Exposure in human and animal health risk assessment. In the ecological area, these include lethal dose (LD50), effect concentration (EC5/ECx), no (adverse) effect concentration/dose (NOEC/NOAEC/NOAED), no (adverse) effect level (NEL/NOAEL), hazard concentration (HC5/HCx) derived from a Species Sensitivity Distributions (SSD) for the ecosystem (EFSA Scientific Committee,2018). Citation: DOI 10.5281/zenodo.4740174

Reference point information of this compound is not available!

Reference Value

Reference Value : The estimated maximum dose (on a body mass basis) or the concentration of an agent to which an individual may be exposed over a specified period without appreciable risk. Reference values are established by applying an uncertainty factor to the reference point. Examples of reference values in human health include acceptable daily intake (ADI) for food and feed additives, and pesticides, tolerable upper intake levels (UL) for vitamins and minerals, and tolerable daily intake (TDI) for contaminants and food contact materials. For acute effects and operators, the acute reference dose (ARfD) and the acceptable operator exposure level (AOEL). In animal health and the ecological area, these include safe feed concentrations and the Predicted no effect concentration (PNEC) respectively (EFSA Scientific Committee, 2018). Citation: DOI 10.5281/zenodo.4740174

OUTPUT ID	ASSESSMENT	QUALIFIER	VALUE	UNIT	POPULATION
2254	TTC Cramer Class I	=	30	µg/kg bw/day	Consumers

Genotoxicity

Author	YEAR	OUTPUT ID	Genotoxicity
EFSA AFC	2008	2254	Not determined

EFSA Outputs

Output ID	Title	DOI	Published
2254	Flavouring Group Evaluation 58 (FGE.58): Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission	doi:10.2903/j.efsa.2008.711	21May2008

Receptors

Receptor information of this compound is not available!

Consensus Spectra

Spectrum Type	Spectrum View	Description	Polarity
Experimental GCMS	view	GCMS	positive
Experimental LCMS	view	LCMS_Positive	positive
Experimental LCMS	view	LCMS_Negative	negative

Content

Compound Summary

4-vinylphenol

Description

4-hydroxystyrene is a member of the class of phenols that is styrene carrying a hydroxy substituent at position 4. It has a role as a human urinary metabolite and a human xenobiotic metabolite. It derives from a hydride of a styrene.

Synonyms

4-Vinylphenol; 4-Hydroxystyrene; 2628-17-3; 4-ETHENYLPHENOL; p-Vinylphenol;

FlavorDB ID

3050

PUBCHEM ID

62453

Molecular Weight

120.15

Molecular Formula

C8H8O

Openeye Can Smiles

C=CC1=CC=C(C=C1)O

IUPAC Inchikey

FUGYGGDSWSUORM-UHFFFAOYSA-N

Network

Shown in network

Similarity

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Content

Compound Summary

4-vinylphenol

Description

4-hydroxystyrene is a member of the class of phenols that is styrene carrying a hydroxy substituent at position 4. It has a role as a human urinary metabolite and a human xenobiotic metabolite. It derives from a hydride of a styrene.

Synonyms

4-Vinylphenol; 4-Hydroxystyrene; 2628-17-3; 4-ETHENYLPHENOL; p-Vinylphenol;

FlavorDB ID

3050

PUBCHEM ID

62453

Molecular Weight

120.15

Molecular Formula

C8H8O

Openeye Can Smiles

C=CC1=CC=C(C=C1)O

IUPAC Inchikey

FUGYGGDSWSUORM-UHFFFAOYSA-N

Network

Shown in network

Similarity

Show/Hide similarity panel

Reference Details

OpenFoodTox: component 4-Vinylphenol

GC-MS Spectrum

GC-MS Spectrum

GC-MS Spectrum