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| CATEGORY | QUALITY | THRESHOLD | OCCURENCE | REFERENCE |
|---|---|---|---|---|
| smell | ammonical, amine | water | details | |
| smell | ammonical, amine | 3.555e+0 µmol/L | water | details |
| Toxicity Summary |
|---|
| Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database |
| IDENTIFICATION AND USE: Isopropylamine is a colorless liquid (a gas above 91 degrees F). It is used as a solvent, intermediate in synthesis of rubber accelerators, pharmaceuticals, dyes, insecticides, bactericides, textile specialties, and surface-active agents, dehairing agent, solubilizer for 2,4-D acid. HUMAN STUDIES: Complaints of nose and throat irritation were reported by volunteer subjects after brief exposures at 10 to 20 ppm. Workers complained of transient visual disturbances (halos around lights) after exposure to the vapor for 8 hours, probably resulting from mild corneal edema, which usually cleared in 3 to 4 hours. ANIMAL STUDIES: A 4-hour exposure of 10,000 mg/cu m (4000 ppm) to 6 rats was not lethal, while all 6 rats died from exposure to 20,000 mg/cu m (8000 ppm). Exposure to a saturated vapor caused the death of all rats within 2 minutes. Isopropylamine produced a severe burn from application of 0.5 mL of a 1% solution. Instillation of 0.005 mL of undiluted compound resulted in severe corneal opacity while 0.5 mL of a 1% solution in water caused severe corneal opacity and iritis. In mice, isopropylamine is essentially an upper respiratory tract-irritating compound. In a one generation reproduction study rats were exposed to isopropylamine at analytical concentrations of 20, 100 or 499 mg/cu m for 6 hr per day (5 days/week) by inhalation (whole body exposure). Clinical signs included incidental fur discoloration and focal hair loss. There were no significant differences in mating and fertility parameters, number of corpora lutea, implantations and resorptions. The was a reduction in mean body weight gain in males in the high dose group. Negative results were reported in bacterial reverse mutation tests for mutagenicity in Salmonella typhimurium (strains included TA1535, TA1537, TA98 and TA100) with and without metabolic activation. The highest non-toxic dose tested was 3333 mg/plate. |
| Source: DrugBank or Hazardous Substances Data Bank (HSDB) |
| Spectrum Type | Spectrum View | Description | Polarity |
|---|---|---|---|
| Experimental GCMS | view | GCMS | positive |