Compound Summary

General Compound Information

Arglabin

Description
Arglabin is an organic heterotetracyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-dimethyl-1,3a,4,5,6,7-hexahydroazulen-5-yl group in which the double bond in the 7-membered ring has been epoxidised and in which the hydroxy group and the carboxy group have undergone formal condensation to give the corresponding gamma-lactone. It is found in Artemisia glabella. Arglabin-DMA HCl, the hydrochloride salt of the adduct resulting from the conjugate addition of dimethylamine to the ene-lactone moiety, has been successfully used in Khazakhstan for the treatment of breast, colon, ovarian and lung cancers. It has a role as an antineoplastic agent and a metabolite. It is an organic heterotetracyclic compound, a gamma-lactone, an epoxide and a sesquiterpene lactone.
Synonyms
Arglabin;  84692-91-1;  (+)-arglabin;  YS8UOP7QZ1;  CHEBI:73228;
FlavorDB ID
56
PUBCHEM ID
5574924
Molecular Weight
246.3
Molecular Formula
C15H18O3
Openeye Can Smiles
CC1=CCC23C1C4C(CCC2(O3)C)C(=C)C(=O)O4
IUPAC Inchikey
UVJYAKBJSGRTHA-CUZKYEQNSA-N
Similarity
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Compound Classification
  • ClassyFire Ontology
Compound Quality
Quality information of this compound is not available!
Compound Toxicity
Toxicity and Food Additive Safety of this compound is not available!
Receptors
Receptor REFERENCE EC50 [µM] Effective Concentration [µM]
TAS2R10 details Activated 100.00
TAS2R14 details Activated 100.00
TAS2R43 details Activated 3.00
TAS2R46 details Activated 3.00
GC-MS Consensus Spectra
GC-MS Consensus Spectra information of this compound is not available!