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ClassyFire Ontology
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| CATEGORY | QUALITY | THRESHOLD | OCCURENCE | REFERENCE |
|---|---|---|---|---|
| smell | 7.968e-4 µmol/L | details | ||
| smell | green, grassy | 3.994e-4 µmol/L | details | |
| smell | green, grassy | 3.994e-4 µmol/L | details | |
| smell | green, grassy | 2.396e-2 µmol/L | details | |
| smell | green, grassy | 9.984e-2 µmol/L | details | |
| smell | grassy | 2.396e-2 µmol/L | guava | details |
| smell | grassy | 2.396e-2 µmol/L | guava | details |
| smell | 1.577e+0 µmol/L | bartlett pear brandy | details | |
| smell | green, grassy | 1.577e+0 µmol/L | bartlett pear brandy | details |
| smell | green | 2.396e-2 µmol/L | chicken egg omlette | details |
| smell | green, grasy | 8.776e-1 µmol/L | rum | details |
| smell | 2.396e-2 µmol/L | licorice | details | |
| smell | grassy, green | 2.396e-2 µmol/L | tomato | details |
| smell | green, grassy | 2.396e-2 µmol/L | orange juice | details |
| smell | 4.200e+1 µg/kg | gluten-free rice breadwheat bread | details | |
| smell | green, grassy | 2.396e-2 µmol/L | jackfruit pulp | details |
| smell | green, grasy | 2.396e-2 µmol/L | cempedak | details |
| smell | grassy, fatty, lettuce heart | water | details | |
| smell | grassy, fatty, lettuce heart | 4.496e-2 µmol/L | water | details |
| Toxicity Summary |
|---|
| Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database |
| IDENTIFICATION AND USE: Hexaldehyde is a colorless liquid. It is not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. Hexanal is used in fruit flavors and, when highly diluted, in perfumery for obtaining fruity notes. It is also used in organic synthesis of plasticizers, rubber chemicals, dyes, synthetic resins, insecticides. HUMAN EXPOSURE AND TOXICITY: Twelve healthy volunteers were exposed to 0, 2, and 10 ppm n-hexanal for 2 hours at rest in a balanced order. Ratings of discomfort in the eyes and nose, solvent smell, and headache increased significantly with the level of exposure. Frequency of blinking was significantly increased at 10 ppm. No effects on pulmonary function and nasal swelling were detected, except a not-significant tendency to increased nasal obstruction at 10 ppm. No clear effects on plasma inflammatory markers (C-reactive protein and interleukin-6) were observed. /It was concluded that/ two hours of exposure to n-hexanal results in mild irritation at 10 ppm, with no apparent adversity at 2 ppm. n-Hexanal at 0.1% depressed motility of human spermatozoa but never rendered the sperm completely immotile. The increased concentrations of lower molecular weight aldehydes, including hexanal, may interfere with cholesterol transport and gap junctional intercellular communication. ANIMAL STUDIES: Acute exposures to the concentrated vapor for 1 hour or to 2000 ppm for 4 hours result in mortality to rats and is cytotoxic to rat hepatocytes. Rats receiving diets containing hexyl aldehyde for 3 wk showed decrease in serum cholesterol and triglyceride. Hexanal stimulates dopamine release but does not inhibit dopamine uptake in the brain striatum of rats. Hexanal influenced the length of time virgin female mice engage in the maternal crouching behavior. Hexanal was mutagenic in mammalian cells. Hexanal produced DNA single-strand breaks, or lesions which were converted to breaks in alkali. |
| Source: DrugBank or Hazardous Substances Data Bank (HSDB) |
| Food Additive Safety (OFAS) |
|---|
| HEXANAL is used for FLAVORING AGENT OR ADJUVANT. More food additive safty information please view GRAS report. |