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|smell||soapy, citrus-like||8.580e-5 µmol/L||details|
|smell||citrus-like, green||2.652e-2 µmol/L||details|
|smell||citrus-like, green||5.382e-2 µmol/L||details|
|smell||citrus-like||2.652e-3 µmol/L||chicken egg omlette||details|
|smell||citrus-like, green||2.652e-2 µmol/L||orange juice||details|
|smell||citrusy, soapy||2.652e-2 µmol/L||jackfruit pulp||details|
|smell||citrus-like, soap-like||2.652e-2 µmol/L||cempedak||details|
|Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database|
|IDENTIFICATION AND USE: Octylaldehyde (Octanal) is a colorless liquid. It is employed in the perfume industry for the preparation of synthetic citrus oils and for the synthesis of alpha-hexylcinnamaldehyde. |
HUMAN STUDIES: In vitro in human A549 cells octanal affects the expression of several chemokines and inflammatory cytokines and increases the levels of interleukin 6 (IL-6) and IL-8 released. Microarray analysis identified 15 miRNAs that were differentially expressed in octanal-exposed A549 human alveolar cells.
ANIMAL STUDIES: It induced a significant decrease in the number of live pups in rats but only at a dose which causes maternal toxicity. Octanal was tested in Salmonella typhimurium TA98, TA100, TA1535 and TA1537 with and without metabolic activation. No cytotoxic or genotoxic effects were observed.
ECOTOXICITY STUDIES: A membrane damage mechanism involving membrane peroxidation might contribute to the antifungal activity of octanal against P. digitatum spores. Aflatoxin production by the fungus Aspergillus parasiticus was stimulated by octanal.
|Source: DrugBank or Hazardous Substances Data Bank (HSDB)|
|Food Additive Safety (OFAS)|
|OCTANAL is used for FLAVORING AGENT OR ADJUVANT. More food additive safty information please view GRAS report.|
|Receptor||REFERENCE||EC50 [µM]||Effective Concentration [µM]|