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ClassyFire Ontology
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| CATEGORY | QUALITY | THRESHOLD | OCCURENCE | REFERENCE |
|---|---|---|---|---|
| smell | cooked potato-like | 4.000e-1 µmol/L | details | |
| smell | cooked potato-like | 4.128e-3 µmol/L | details | |
| smell | cooked potato-like | 1.344e-2 µmol/L | details | |
| smell | cooked potato-like | 4.128e-3 µmol/L | guava | details |
| smell | cooked potato-like | 3.840e-3 µmol/L | details | |
| smell | potato-like | 4.128e-3 µmol/L | chicken egg omlette | details |
| smell | cooked potato-like | 4.128e-3 µmol/L | licorice | details |
| smell | cooked potato-like | 4.128e-3 µmol/L | mango | details |
| smell | cooked potato-like | 4.128e-3 µmol/L | licorice | details |
| smell | 4.128e-3 µmol/L | curry leaf | details | |
| smell | 4.128e-3 µmol/L | blanched prawnfried prawn | details | |
| smell | cooked potato-like | 4.128e-3 µmol/L | tomato | details |
| smell | cooked potato-like | 5.088e-3 µmol/L | red wine | details |
| smell | cooked potato-like | 4.128e-3 µmol/L | jackfruit pulp | details |
| smell | cooked potato-like | 4.128e-3 µmol/L | cempedak | details |
| smell | cooked potato-like | 4.128e-3 µmol/L | barley tea | details |
| Toxicity Summary |
|---|
| Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database |
| IDENTIFICATION AND USE: 4-Thiapentanal is a colorless to amber liquid. The chemical is used as intermediate in chemical industry for the production of the amino acid methionine and methionine-hydroxyl analog. A minor use as a food flavoring agent and tobacco ingredient has been identified. HUMAN STUDIES: The activities of butyryl and acetylchoninesterase decreased with increases of occupational service time in the blood of apparently healthy workers exposed to the chemical. ANIMAL STUDIES: 4-Thiapentanal was irritating to the skin and mucous membranes. It had demonstrated a skin sensitizing potential in a guinea pig test. With regard to respiratory irritation it is unclear from the existing studies whether the observed local effects in inhalation studies are attributable to 4-thiapentanal or acrolein that can be enriched in the vapor phase under the test conditions. Exposure of rats to a statically generated saturated atmosphere killed all 5 males with a 40 min exposure and all 5 females with a 24 min exposure. In contrast, a 4-hr exposure of rats to a dynamically generated saturated vapor atmosphere did not produce any mortalities or signs of toxicity. After 28 days oral administration of 4-thiapentanal by gavage to rats a slight hemolytic effect with reduced red blood cell counts and hemoglobin levels, increases in blood bilirubin levels and indications of increased hematopoiesis in the spleen observed at 521 mg/kg bw/d. Dermal exposure of rats for 9 days (6 hr occluded exposure per day) resulted in a slight decrease in body weight gain at a dose of 527 mg/kg bw/d. No effects on the sex organs of rats (male or female) have been observed in the 9-day inhalation study and the 28-day oral study. 4-Thiapentanal did not reveal any developmental toxicity in a study with rats by the inhalation route at exposure concentrations that were clearly maternally toxic. 4-Thiapentanal did not produce mutagenic activity either in the absence or presence of metabolic activation with a Salmonella typhimurium reverse mutation assay using strains TA98, TA100, TA1535, TA1537 and TA1538. In a mouse lymphoma cell assay, it produced concentration-related increases in mutant colonies, both in the absence and presence of metabolic activation. However, in an in vivo mouse micronucleus study 4-thiapentanal showed a negative result, indicating that the clastogenesis that was demonstrated in an in vitro study does not occur in vivo. |
| Source: DrugBank or Hazardous Substances Data Bank (HSDB) |
| Food Additive Safety (OFAS) |
|---|
| 3-(METHYLTHIO)PROPIONALDEHYDE is used for FLAVORING AGENT OR ADJUVANT. More food additive safty information please view GRAS report. |
| EFSA's chemical Hazards Database : OpenFoodTox |
|---|
| This compound is found in OpenFoodTox with the name: 3-(Methylthio)propionaldehyde |