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Compound Summary

General Compound Information

1-methoxy-4-(1-propenyl)benzene (p-propenylanisole)

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Description

Anethole is a monomethoxybenzene that is methoxybenzene substituted by a prop-1-en-1-yl group at position 4. It has a role as a plant metabolite.

Synonyms

ANETHOLE; trans-Anethole; 4180-23-8; 104-46-1; (E)-Anethole;

p-Propenylanisole;(E)-1-Methoxy-4-(prop-1-en-1-yl)benzene;Anise camphor;Isoestragole;4-Propenylanisole;Monasirup;cis-Anethol;(E)-p-Propenylanisole;Anethol;trans-p-Propenylanisole;trans-Anethol;p-Anethole;Anethole, trans;Anisole, p-propenyl-;(E)-Anethol;Aniskampfer;1-Methoxy-4-(prop-1-en-1-yl)benzene;Anethole, trans-;trans-1-p-Anisylpropene;1-methoxy-4-[(E)-prop-1-enyl]benzene;p-1-Propenylanisole;(E)-1-(4-Methoxyphenyl)propene;1-Methoxy-4-propenylbenzene;1-methoxy-4-[(1E)-prop-1-en-1-yl]benzene;4-Methoxypropenylbenzene;trans-4-(1-Propenyl)anisole;FEMA No. 2086;Benzene, 1-methoxy-4-(1-propenyl)-;(E)-1-Methoxy-4-(1-propenyl)benzene;trans-p-Methoxy-beta-methylstyrene;1-Methoxy-4-(1-propenyl)benzene;4-Methoxy-1-propenylbenzene;p-Propenylphenyl methyl ether;Propene, 1-(p-methoxyphenyl)-;t-anethole;1-Propene, 1-(4-methoxyphenyl)-;Anethole (natural);Benzene, 1-methoxy-4-(1-propenyl)-, (E)-;trans-p-Anethole;Benzene, 1-methoxy-4-(1E)-1-propenyl-;NSC 4018;Q3JEK5DO4K;NSC-209529;p-Methoxy-.beta.-methylstyrene;DTXSID9020087;Trans-Anethole ((E)-Anethole);CHEBI:35616;NSC4018;Anethole (NF);Anethole [NF];(E)-1-p-Methoxyphenylpropene;trans-1-Methoxy-4-(1-propenyl)benzene;Benzene, 1-methoxy-4-(1-propen-1-yl)-;Methoxy-4-propenylbenzene;MFCD00009284;trans-1-(p-Methoxyphenyl)-1-propene;trans-1-(4-Methoxyphenyl)-1-propene;DTXCID0086;DTXCID2087;1-Methoxy-4-((1E)-1-propenyl)benzene;26795-32-4;E-anethole;trans-Anethole (natural);1-(4-Methoxyphenyl)-1(3)-propene;Acintene O;(E)-1-methoxy-4-(prop-1-enyl)benzene;p-(1-Propenyl)anisole;CAS-104-46-1;4-(1-propenyl)anisole;Propenylanisole, p-, (E)-;CAS-4180-23-8;Anethol (synthetic);Anisole, p-propenyl-, trans-;Anisole, p-propenyl-, (E)-;CCRIS 2481;1-(p-Methoxyphenyl)propene;1-p-Methoxyphenylpropene, trans-;Caswell No. 051B;p-Propenylmethoxybenzene;FEMA Number 2086;SR-05000001866;1-(methyloxy)-4-[(1E)-prop-1-en-1-yl]benzene;4-06-00-03796 (Beilstein Handbook Reference);EINECS 224-052-0;UNII-Q3JEK5DO4K;Methoxy-beta-methylstyrene, trans-p-;CHEBI:2716;DTXSID4020086;NSC 209529;p-Methoxy-beta-methylstyrene;BRN 0636190;trans-1-(p-Methoxyphenyl)propene;UNII-A79C64YD3Q;1-Methoxy-4-(1-propenyl)benzene, (E)-;CCRIS 6211;1-Methoxy-4-[1-propenyl]benzene #;Anisole, trans-;HSDB 1427;NCGC00091493-01;Benzene, 1-methoxy-4-(propenyl)-;EINECS 203-205-5;EINECS 256-753-2;(E)?-Anethole;EPA Pesticide Chemical Code 015604;BRN 0774229;Benzene, 1-methoxy-4-(propen-1-yl)-;trans-Anethole, 99%;ANETHOLE [INCI];ANETHOLE [FCC];1-Methoxy-4-(1E)-1-propen-1-ylbenzene;AI3-00380;ANETHOLE [II];ANETHOLE [MI];4-trans-propenyl-anisole;ANETHOLE [VANDF];Spectrum5_000727;ANETHOLE [USP-RS];ANETHOLE [WHO-DD];ANETHOLE, (E)-;EC 224-052-0;ghl.PD_Mitscher_leg0.12;SCHEMBL48599;BSPBio_002818;trans-p-Methoxypropenylbenzene;2-06-00-00523 (Beilstein Handbook Reference);SPECTRUM1503705;TRANS-ANETHOLE [FHFI];WLN: 2U1R DO1;Anethol, natural, 99%, FG;A79C64YD3Q;CHEMBL452630;WLN: 2U1R DO1 -T;HMS1922I20;HMS2089P20;HMS2093I09;HMS3885E16;Pharmakon1600-01503705;ZINC967630;trans-Anethole, analytical standard;HY-B0900;NSC-4018;Tox21_111139;Tox21_202001;Tox21_202282;Tox21_300132;BBL027751;CCG-38720;NSC209529;NSC758626;s3779;STK801277;trans-p-Methoxy-.beta.-methylstyrene;trans-Anethole, >=99%, FCC, FG;AKOS000121299;Tox21_111139_1;DS-2756;NSC-758626;methyl 4-(prop-1-en-1-yl)phenyl ether;NCGC00091493-02;NCGC00091493-03;NCGC00091493-04;NCGC00091493-05;NCGC00091493-06;NCGC00091493-07;NCGC00091493-09;NCGC00254015-01;NCGC00259550-01;NCGC00259831-01;AC-34207;LS-13792;SBI-0052758.P002;trans-Anethole, purum, >=98.0% (GC);Benzene,1-Methoxy-4-(1-Propenyl)-,(E)-;P0494;S3990;EN300-18430;A14711;Benzene, 1-methoxy-4-(1E)-1-propen-1-yl-;D02377;D70168;AB00053256-02;AB00053256_03;EN300-1695718;A873002;Q255564;(E)-ANETHOLE (CONSTITUENT OF MYRRH) [DSC];Q-201853;SR-05000001866-1;SR-05000001866-2;W-108812;BRD-K49060658-001-01-5;trans-Anethole, primary pharmaceutical reference standard;Z2315575049;Anethole, United States Pharmacopeia (USP) Reference Standard;BENZENE,1-METHOXY,4-PROPENYL(TRANS) TRANS ANETHOL;trans-Anethole, Pharmaceutical Secondary Standard; Certified Reference Material;

FlavorDB ID

3097

PUBCHEM ID

Molecular Weight

148.2 Molecular Formula

C10H12O

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IUPAC Inchikey

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Similarity

CATEGORY	QUALITY	THRESHOLD	OCCURENCE	REFERENCE
smell		1.012e-1 µmol/L	licorice	details
smell	aniseed-like	1.012e-1 µmol/L		details
smell	aniseed-like	4.926e-1 µmol/L		details

Toxicity Summary
Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database

Food Additive Safety (OFAS)
TRANS-ANETHOLE is used for FLAVORING AGENT OR ADJUVANT. More food additive safty information please view GRAS report.

EFSA's chemical Hazards Database : OpenFoodTox
This compound is found in OpenFoodTox with the name: Trans-anethole

Reference point : Defined point on an experimental dose–response relationship for the critical effect. This term is synonymous to Point of departure (USA). Reference points include the lowest or no observed adverse effect level (LOAEL/NOAEL) or benchmark dose lower confidence limit (BDML), used to derive a reference value or Margin of Exposure in human and animal health risk assessment. In the ecological area, these include lethal dose (LD50), effect concentration (EC5/ECx), no (adverse) effect concentration/dose (NOEC/NOAEC/NOAED), no (adverse) effect level (NEL/NOAEL), hazard concentration (HC5/HCx) derived from a Species Sensitivity Distributions (SSD) for the ecosystem (EFSA Scientific Committee,2018). Citation: DOI 10.5281/zenodo.4740174

Output ID	SPECIES	Route	Duration Days	END POINT	QUALIFIER	VALUE	UNIT	EFFECT	Toxicity
145	Rat	Not reported	90	NOAEL	=	300	mg/kg bw/day	clinical chemistry	systemic
2858	Rat	Not reported	90	NOAEL	<=	400	mg/kg bw/day	clinical chemistry	hepatotoxicity

Reference Value

Reference Value : The estimated maximum dose (on a body mass basis) or the concentration of an agent to which an individual may be exposed over a specified period without appreciable risk. Reference values are established by applying an uncertainty factor to the reference point. Examples of reference values in human health include acceptable daily intake (ADI) for food and feed additives, and pesticides, tolerable upper intake levels (UL) for vitamins and minerals, and tolerable daily intake (TDI) for contaminants and food contact materials. For acute effects and operators, the acute reference dose (ARfD) and the acceptable operator exposure level (AOEL). In animal health and the ecological area, these include safe feed concentrations and the Predicted no effect concentration (PNEC) respectively (EFSA Scientific Committee, 2018). Citation: DOI 10.5281/zenodo.4740174

OUTPUT ID	ASSESSMENT	QUALIFIER	VALUE	UNIT	POPULATION
145	ADI	=	2	mg/kg bw/day	Consumers
145	MSI/FC	=	3	mg/kg bw/day	Cattle for meat production
145	MSI/FC	=	3	mg/kg bw/day	Cattle for meat production - less than 1 year old
145	MSI/FC	=	3	mg/kg bw/day	Cattle for milk production
145	MSI/FC	=	3	mg/kg bw/day	Chicken for egg production
145	MSI/FC	=	3	mg/kg bw/day	Chicken for meat production
145	MSI/FC	=	3	mg/kg bw/day	Pigs - less than 1 year old
145	MSI/FC	=	3	mg/kg bw/day	Pigs for meat production
145	MSI/FC	=	3	mg/kg bw/day	Pigs for reproduction
145	MSI/FC	=	3	mg/kg bw/day	Turkeys for meat production
2858	ADI	<=	2	mg/kg bw/day	Consumers

Genotoxicity

Author	YEAR	OUTPUT ID	Genotoxicity
EFSA FEEDAP	2011	145	Negative
EFSA FEEDAP	2012	246	Negative
EFSA FEEDAP	2016	2858	No data

EFSA Outputs

Output ID	Title	DOI	Published
145	Scientific Opinion on the safety and efficacy of allylhydroxybenzenes (chemical group 18) when used as flavourings for all animal species	doi:10.2903/j.efsa.2011.2440	02Dec2011
246	Scientific Opinion on safety and efficacy of CRINA Poultry Plus (preparation of benzoic acid and essential oil compounds) as feed additive for chickens for fattening	doi:10.2903/j.efsa.2012.2620	23Mar2012
2858	Safety and efficacy of BIOSTRONG 510 (essential oil of thyme and star anise) for chickens and minor avian species for fattening and rearing to point of lay	doi:10.2903/j.efsa.2016.4351	08Jul2016

Receptors

Receptor	REFERENCE	EC50 [µM]	Effective Concentration [µM]
OR1G1	details	Activated
OR52D1	details	Activated

Consensus Spectra

Spectrum Type	Spectrum View	Description	Polarity
Experimental GCMS	view	GCMS	positive

Content

Compound Summary

1-methoxy-4-(1-propenyl)benzene (p-propenylanisole)

Description

Anethole is a monomethoxybenzene that is methoxybenzene substituted by a prop-1-en-1-yl group at position 4. It has a role as a plant metabolite.

Synonyms

ANETHOLE; trans-Anethole; 4180-23-8; 104-46-1; (E)-Anethole;

FlavorDB ID

3097

PUBCHEM ID

637563

Molecular Weight

148.2

Molecular Formula

C10H12O

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IUPAC Inchikey

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Content

Compound Summary

1-methoxy-4-(1-propenyl)benzene (p-propenylanisole)

Description

Anethole is a monomethoxybenzene that is methoxybenzene substituted by a prop-1-en-1-yl group at position 4. It has a role as a plant metabolite.

Synonyms

ANETHOLE; trans-Anethole; 4180-23-8; 104-46-1; (E)-Anethole;

FlavorDB ID

3097

PUBCHEM ID

637563

Molecular Weight

148.2

Molecular Formula

C10H12O

Openeye Can Smiles

CC=CC1=CC=C(C=C1)OC

IUPAC Inchikey

RUVINXPYWBROJD-ONEGZZNKSA-N

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Reference Details

Reference Details

Reference Details

OpenFoodTox: component Trans-anethole

Reference Details

Reference Details

GC-MS Spectrum