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Compound Summary

General Compound Information

Parthenolide

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Description

Parthenolide is a sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium). It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a peripheral nervous system drug, an inhibitor and a drug allergen.

Synonyms

parthenolide; 20554-84-1; (-)-Parthenolide; CHEBI:7939; CHEMBL465158;

MFCD00134592;(1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one;2RDB26I5ZB;4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone;29552-41-8;partenolide;NSC-157035;Prestwick2_000550;Prestwick3_000550;PARTHENOLIDE [MI];Epitope ID:115014;PARTHENOLIDE [INCI];SCHEMBL8220;BSPBio_000599;BSPBio_001308;MLS002153872;PARTHENOLIDE [USP-RS];PARTHENOLIDE [WHO-DD];BPBio1_000659;parthenolide-(alternate-stereo);SCHEMBL13367522;BCBcMAP01_000041;Parthenolide, >=98% (HPLC);HMS1361B10;HMS1569N21;HMS1791B10;HMS1989B10;HMS2096N21;HMS3402B10;HMS3713N21;BCP10404;EX-A5460;HY-N0141;PTL;ZINC4492886;BDBM50552137;AKOS016010226;CCG-208244;CS-1919;IDI1_033778;NCGC00163415-01;NCGC00163415-04;AS-17479;SMR001233226;AB00513860;EN300-21037378;PARTHENOLIDE (CONSTITUENT OF FEVERFEW) [DSC];Q-100253;(-)-Parthenolide; NSC-157035; NSC 157035; NSC157035;Parthenolide, United States Pharmacopeia (USP) Reference Standard;(1aR,4E,7aS,10aS,10bR)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one;(1AR,4E,7AS,10AS,10BS)-2,3,6,7,7A,8,10A,10B-OCTAHYDRO-1A,5-DIMETHYL-8-METHYLENEOXIRENO(9,10)CYCLODECA(1,2-B)FURAN-9(1AH)-ONE;(1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.0,2,4]tetradec-7-en-13-one;(3aS,10R,11R,11aS,6E)-3-Methylene-6,10-dimethyl-10,11-epoxy-1-oxa-2,3,3a,4,5,8,9,10,11,11a-decahydro-1H-cyclopentacyclodecene-2-one;4,5.ALPHA.-EPOXY-6.BETA.-HYDROXY-GERMACRA-1(10),11(13)-DIEN-12-OIC ACID .GAMMA.-LACTONE;

FlavorDB ID

4200

PUBCHEM ID

7251185

Molecular Weight

248.32

Molecular Formula

C15H20O3

Openeye Can Smiles

CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C

IUPAC Inchikey

KTEXNACQROZXEV-PVLRGYAZSA-N

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Compound Classification

Classification (Parent Nodes)

ClassyFire Ontology

Compound Quality

Quality information of this compound is not available!

Compound Toxicity and Food Additive Safety (OFAS)

Toxicity Summary
Link to the Distributed Structure-Searchable Toxicity (DSSTox) Database

Receptors

Receptor	REFERENCE	EC50 [µM]	Effective Concentration [µM]
TAS2R1	details	Activated	100.00
TAS2R4	details	Activated	30.00
TAS2R8	details	Activated	100.00
TAS2R10	details	69.10	30.00
TAS2R14	details	10.00	3.00
TAS2R31	details	Activated	100.00
TAS2R46	details	Activated	1.00

GC-MS Consensus Spectra

GC-MS Consensus Spectra information of this compound is not available!